Cerebrolysin analogues are cheap. The drug 'Cerebrolysin'

Nootropic drugs are necessary to protect the brain from overload, as well as to restore the body after suffering ischemic lesions. One of the most effective drugs group is Cerebrolysin.

Description and characteristics

Medicines that have a nootropic effect on the body activate the mechanisms of protection, restoration and renewal of the body, cells. The systematic use of the drug helps:

• reduce heart attack
• increase neuronal activity and work of the GM;
• improve blood microcirculation in vessels and capillaries;
• eliminate neurological and cognitive pathological changes different type.

Patients who depend on someone else's help improve their ability to perform simple daily tasks and self-care. The drug also allows you to slow down the active development of neurodegenerative processes. During the experiments, a range of possibilities for recovery and slowing down destruction during the progression of Alzheimer's disease was established.

The drug accelerates the recovery processes of the body, but does not affect the immune system.

The main substance of the composition is cerebrolysin, which is a peptide compound obtained from the brain of pigs. Release form - solution for injections (5%) in ampoules. The cost of packaging in pharmacy chains is 1000-1100 rubles. Sale is carried out by prescription.

Indications and purpose

The main purpose of Cerebrolysin is to restore the higher abilities of the brain during or after destructive changes in its structure and cells. Indications for use include conditions and diseases:

An indication for use can also be an endogenous depressive state, in which resistance to antidepressants is observed. It is allowed to use in children if there are indications under the supervision of a pediatrician and a neurologist. In such cases, a correction of the standard dosage is required. It is possible to include Cerebrolysin in the composition complex therapy.

How to choose an analog?

Selection of similar medicines the attending physician deals with indications and individual characteristics of patients. Replacement is usually required if the selected drug is not effective enough or the patient is hypersensitive to its composition. The effectiveness of therapy is studied additionally, including experimentally.

Dosages in the duration of the course of all drugs are selected individually.

The selection criterion can also be a list of contraindications.

Modern nootropic drugs in the composition contain natural ingredients (peptides), as well as chemicals. This distinguishes drugs by contraindications, side effects and mechanism of action. It is recommended to inject peptide drugs in the morning or in the evening, chemical drugs must be taken according to the schemes established by the instructions.

Cavinton

The drug is classified as a cerebrovasodilator. The drug helps to improve blood circulation, improves brain metabolism, stimulates the production and metabolism of serotonin, norepinephrine. Used in the fields of medicine:

The medication is used in the form of injections and droppers. The tablet form is sold for oral administration. Not applicable in pediatrics. The average cost of a package is 200-250 rubles.

Mexidol

The drug is available in the form of tablets and solutions for intravenous and intramuscular injections. It has a nootropic, antioxidant, membrane-stabilizing effect on the body. With systematic use, the drug improves the higher abilities of the brain, eliminates the symptoms of hypoxia, ischemia, shock, and restores blood circulation.

Additionally, it is used for craniocerebral injuries, glaucoma, vegetovascular dystonia, myocardial infarction, circulatory disorders of the brain. The average cost of a drug in a pharmacy is 100-150 rubles.

Cerepro

Choline alfoscerate (the main component of Cerepro) improves the cognitive abilities of the brain, regulates reactions, and restores GM activity. The drug improves the condition of patients after traumatic brain injury, dementia, senile destructive changes, stroke.

Do not use the drug for acute forms hemorrhagic lesions of the GM. The medicine in pediatrics is used only at increased risks with a doctor's prescription. The cost of packaging in pharmacy chains is 150-200 rubles.

Gliatilin

Active ingredient composition - choline alfoscerate, therefore the drug is an analogue of Cerepro in composition and mechanism of action. The drug shows the best results in the recovery of patients after a stroke, traumatic brain injury.

In pediatrics, the drug Gliatilin is used with caution, since there is insufficient data on experimental use in pediatric patients. This analogue is more expensive. The average price per package in the regions of Russia is 500-550 rubles.

Piracetam

The main substance (piracetam) has a complex effect on the brain using several mechanisms at once. The component modulates the rate of excitation behavior in GM cells, improves blood microcirculation, dilates blood vessels.

In three forms of release, it helps to prevent and eliminate senile dementia, coma of various types, vertigo. With regular use, the drug restores the activity of the GM and the whole body after trauma, surgery. Packing price - 20-40 rubles.

Cerebrolysate

The basis of the composition of Cerebrolysate is the hydrolyzate of GM cattle. The drug is a close analogue of Cerebrolysin, has a similar mechanism of action and a list of indications for use.

It is allowed to use the medicine in childhood. It allows you to restore concentration, reduce aggression in a child and adolescent. Cerebrolysate in three forms has a small number of contraindications and practically does not cause adverse reactions. Price - 250-280 rubles.

Ceraxon

The drug is available in the form of a liquid for oral administration, tablets. The basis of the drug (citicoline) restores the cognitive abilities of the brain, improves concentration, reduces destructive changes in brain tissue. These characteristics make it possible to use in the rehabilitation of traumatic injuries, strokes.

The medicine also helps to fight the effects of chronic and acute hypoxia, improves blood microcirculation. The cost of the medicine is 680-700 rubles.

Cereton

The basis of the drug is choline alfoscerate. The drug is available in two forms (injections, capsules) and has a nootropic effect on the body. The systematic use of drugs enhances cerebral blood supply, stimulates cellular metabolism.

Choline alfoscerate is included in other analogues, but when replacing it is necessary to take into account the amount active substance in dosage.

GM cognitive indicators improve during the recovery period after injuries, strokes, ischemia, and senile dementia. The drug is produced in Russia. The average cost of a package is 150-200 rubles.

Other analogues of the drug

To restore cognitive abilities and brain functionality, a huge number of analogues better and worse than Cerebrolysin have been developed.

In practice, medicines are used in the form of solutions for intramuscular and intravenous administration, tablets.

What is better Cerebrolysin or Cortexin?

Cortexin - more cheap analogue Cerebrolysin in ampoules. The cost of packaging the product is 700-800 rubles. The composition of the drug is similar. The active ingredient is GM cattle polypeptides. The drug helps to restore the functionality of the brain, has a nootropic and antioxidant effect.

Many are interested in the answer to the question of what is more effective: Cerebrolysin or Cortexin, which is better to choose. Cortexin has a narrower range of applications, but is used to restore the body after infectious lesions. The manufacturer of the drug is Geropharm LLC, Russia.

What is better Cerebrolysin or Actovegin?

Actovegin is a restorative drug for improving blood circulation, metabolic processes in the body after degenerative diseases, traumatic injuries. The drug is similar in terms of the type of action, but has a different composition. The active component is deproteinized hemoderivative from the blood of calves.

The answer to the question of whether Cerebrolysin or Actovegin, which is better, is more unambiguous due to the characteristics of the latter. The drug has three forms of implementation: ointment, injection, tablets. Therefore, it is applied more widely. The disadvantage of the drug is a large number of restrictions on its use. The manufacturer of the drug is Nycomed Austria GmbH, Austria. The average cost is 250-300 rubles.

Important information about Cerebrolysin treatment

Cerebrolysin is a drug created on the basis of cattle brain peptides. The action of the drug today is not fully understood, therefore, during the treatment period, pronounced side effects may occur. The effectiveness of the drug has been proven experimentally and by observation of patients, but there is not enough information about the pharmacological characteristics of the composition. Therefore, the drug and analogues must be used with caution.

Cerebrolysin analogues are cheaper

Cerebrolysin belongs to nootropic drugs, which includes low molecular weight peptides, which are obtained from the tissues of the brain of pigs. Despite the fact that clinical efficacy medication has not been proven at the moment, cerebrolysin and its analogues are actively prescribed by neurologists and psychiatrists.

Testimonies of patients in most cases indicate an improvement in the clinical picture of the course of the disease after treatment with cerebrolysin, and also note the drug with a positive effect on the brain. It is worth knowing that the drug Cerebrolysin has a certain list of contraindications, which does not recommend its use in the treatment of some patients.

In such situations, patients are prescribed cerebrolysin analogues. In addition, the doctor can prescribe an analogue if the patient asks to prescribe a cheaper drug, because, unfortunately, cheap raw materials did not lead to a low cost of the final drug (the cost of Cerebrolysin starts from 650 rubles).

Cerebrolysate

Cheap analogues of cerebrolysin are not easy to find, but cerebrolysate is one of them. The main difference between cerebrolysate and cerebrolysin is that cerebrolysate is derived from bovine brain cells, not pigs. An analogue is produced in the same forms as Cerebrolysin - in ampoules, in the form of a liquid solution for injections.

Cerebrolysate as an analogue of cerebrolysin is used to treat the following diseases:

• radiculopathy caused by various sources;
• neropathy and myelopathy;
• brain injury;
• as part of complex therapy in the post-stroke state;
• disturbances in the work of the central nervous system caused by starvation of the brain due to its poor blood supply;
• low level of concentration.

List of contraindications

There are a number of situations in which Cerebrolysate should not be used.

1. High sensitivity to the composition of the drug.
2. Pregnancy up to 12 weeks
3. Epilepsy
4. Problems in the work of the kidneys.

With extreme caution, cerebrolysate is prescribed in such cases as:

• baby feeding breast milk;
• second and third trimesters of pregnancy;
• acute renal failure;
• diathesis of allergic etiology.

Cerebrolysate can be attributed to cheap analogues of Cerebrolysin, its price is lower than that of the original, and starts from 180 rubles per pack. The entry of this drug into the niche of cheap analogues of Cerebrolysin makes it an extremely popular drug.

Actovegin

Actovegin is another analogue of cerebrolysin, which is produced from calf red blood cells. The basis for production is its main difference directly from celebrolysin.

There are several types of actovegin release forms:

• ointment;
• cream;
• gel;
• solution for infusion;
• injection.

It should be noted that of all existing forms Cerebrolysin analogues include only solutions for intravenous and intramuscular injection and tablets. Other varieties of forms of the drug are designed to heal damage to the skin and relieve pain in the joints.

Indications for prescribing the drug

Indications for prescribing the drug directly depend on its dosage form, solutions for injections and infusions.

Application

The appointment of a solution for intravenous infusion, as well as for intramuscular injections as an analogue of cerebrolysin, is indicated for such diagnoses as:

• ischemic stroke;
• traumatic brain injury;
• arterial vascular disorders
• trophic ulcers;
• angiopathy;
• diabetic polyneuropathy;
• the presence of wounds;
• restoration of the skin and mucous membranes after radiation therapy.

Tablets

Doctors prescribe Actovegin in tablets to patients to improve their condition during the course of such diseases and conditions as:

• vascular disorders of the brain;
• metabolic disorders of the brain;
• insufficient supply of blood to the brain;
• traumatic brain injury;
• dementia;
• venous vascular disorders;
• arterial vascular disorders;
• trophic ulcers;
• angiopathy;
• diabetic polyneuropathy.

List of contraindications

The list of contraindications to the use of Actovegin is directly related to the form of the prescribed drug.

For infusion solutions and solutions for intramuscular injection

A number of strict contraindications that prohibit the appointment of the drug include:

• slow excretion of fluid by the body;
• decompensated heart failure;
• oliguria;
• anuria;
• swelling of the respiratory system;
• allergy to the composition of the drug.

The appointment of actovegin with extreme caution should be with:

• hypernatremia;
• hyperchloremia;
• pregnancy and breastfeeding (in such a situation, the benefit to the body of the expectant mother should be much higher than all the risks that the fetus will be exposed to during therapy)

For tablets

Actovegin tablets are absolutely contraindicated only if their components are intolerant to the patient's body. In other cases, the use of the drug is permissible. It is worth considering that under certain conditions Actovegin tablets should be taken with extreme caution. These states include:

• heart failure of the second and third degree;
• hyperhydration;
• swelling of the respiratory system;
• anuria;
• oliguria;
• pregnancy;
• feeding the baby with breast milk.

At the risk of getting expressed allergic reaction, in no case should you prescribe actovegin yourself as an analogue of cerebrolysin, especially since this analogue is not included in the category of cheap drugs. The cost of a medicine in the form of solutions is almost equal to the cost of Cerebrolysin, and the cost of tablets goes far beyond the segment of budget (or cheap) medicines, reaching a figure of 1,600 rubles and more.

Cortexin

Cortexin is one of the drugs belonging to the order of nootropics. Cortexin is obtained from cells located in the cerebral cortex of cattle and pigs. The difference between Cortexin and other analogues of Cerebrolysin is a larger range of indications for prescribing at the same time with a smaller list of contraindications and with extremely rarely manifested side effects. The good tolerability of the analogue was the reason that the greatest use of Cortexin is in child psychiatry and neurology. Children under 3 years of age are prescribed it free of charge, while older patients have to purchase Cortexin on their own. Unfortunately, the popularity of the drug did not put Cortexin on the list of cheap drugs.

Indications for prescribing the drug

Cortexin as an analogue of cerebrolysin is prescribed to patients in the following situations:

• disturbances in the blood supply to the brain;
• viral neuroinfections;
• bacterial nature;
• traumatic brain injury;
• asthenic syndrome;
• encephalopathy with various sources;
• vegetative suprasegmental disorders;
• memory problems;
• thinking problems;
• epilepsy;
• encephalitis;
• encephalomyelitis.

• Reduced susceptibility to learning;
• delay in psychomotor development;
• delay in speech development;
• the presence of perinatal CNS injuries.

List of contraindications

• pregnancy;
• lactation;
• allergic to Cortexin.

It should be noted that Cortexin is not the cheapest drug among analogues; moreover, its cost is often higher than the cost of cerebrolysin itself and starts from 750 rubles.

Mexidol

Unlike Cerebrolysin, Mexidol is not a nootropic, but an antioxidant drug. The action of the analog is based on the fact that Mexidol protects cells from excessive oxidation, helps to restore intercellular membranes, and increases the tolerance of hypoxia by tissues. The generic is similar directly to cerebrolysin in that both the original composition and the analogue of the drug activate mental activity, improve memory and increase learning.

The indisputable advantage of Mexidol is its price. Mexidol is the cheapest analogue of Cerebrolysin.

Indications for prescribing the drug

Mexidol is prescribed to the patient in the presence of such diagnoses as:

• acute disorders in the blood circulation of the brain;
• vegetovascular dystonia;
• cardiopsychoneurosis;
• encephalopathy;
• atherosclerosis;
• neuroses;
• panic attacks;
• acute poisoning with neuroleptic drugs;
• alcoholism;
• inflammatory processes in the peritoneum in the acute stage;
• tissue hypoxia;
• extreme environmental conditions.

List of contraindications

Despite numerous positive sides mesidol also has a certain list of contraindications that do not allow the use of this drug.

1. Liver failure.
2. Renal failure.
3. Allergy to the active ingredients of the drug.
4. Pregnancy.
5. Feeding the baby with breast milk.

Mexidol can be confidently included in the segment of cheap medicines. The cost of one package of analogue starts from 40 rubles. The availability of Mexidol (due to the cheap price) provided the drug with exceptional popularity and active use for the treatment of patients in hospitals.

Ceraxon

Ceraxon, like Cerebrolysin, belongs to nootropic drugs designed to fight brain and central nervous system damage. This is an advanced development of Russian scientists. The main difference between the drugs is the base. For the fundamental component of ceraxon, a synthetically created substance, citicoline, was taken.

Indications for prescribing the drug

Ceraxon as an analogue to Cerebrolysin is prescribed when the following diagnoses are detected:

• recovery in the post-stroke period;
• the presence of a traumatic brain injury;
• acute period of ischemic stroke;
• the presence of cognitive disorders, the cause of which is degenerative and vascular diseases brain;
• the presence of behavioral disorders, the cause of which is degenerative and vascular diseases of the brain.

List of contraindications

1. Expressed vagotonia.
2. Sensitivity to the components of the drug.
3. Pregnancy.
4. lactation period.

In addition, ceraxon cannot be used as an analogue of cerebrolysin if the patient is under 18 years of age.

It will not work to save money by purchasing ceraxon as an analogue of Cerebrolysin. This drug can not be called cheap. In most pharmacies, the cost of both drugs is approximately the same.

Each of the considered nootropic substitutes, Cerebrolysin, has its own advantages and disadvantages, including the presence of side effects and cheaper or more expensive cost. Asking the question what is better cerebrolysate or cerebrolysin, cortexin or another analogue of cerebrolysin, the patient should keep in mind that the drug is prescribed by the doctor based on the patient's history and clinical picture the use of the drug, so if the attending physician has prescribed Cerebrolysin, then the patient should obey and take this particular drug, and not its cheaper or more expensive counterparts.

Cortexin - official instructions for use. Prescription drug, information intended for healthcare professionals only!

Nootropic drug

pharmachologic effect

Nootropic drug.

Contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of not more than 10,000 Da, isolated from the cerebral cortex of cattle or pigs not older than 12 months of age. Penetrates through the BBB directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.

Nootropic action

Improves the higher functions of the brain, learning and memory processes, concentration, stability under various stressful conditions.

Neuroprotective action

Protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant action

Inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.

Tissue-specific action

Activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the functions of the cerebral cortex and the overall tone of the nervous system.

Mechanism of action

The mechanism of action of Cortexin is due to the activation of peptides of neurons and neurotrophic factors of the brain; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectrical activity; prevention of education free radicals(products of lipid peroxidation).

Pharmacokinetics

The complex composition of Cortexin, active substance which is a complex of polypeptide fractions, does not allow for the usual pharmacokinetic analysis of individual components.

Indications for use of the drug CORTEKSIN®

In the complex therapy of the following conditions and diseases:

• disorders of cerebral circulation;
• traumatic brain injury and its consequences;
• encephalopathy of various origins;
• cognitive impairment (including memory and thinking disorders);
• acute and chronic encephalitis and encephalomyelitis;
• epilepsy;
• asthenic conditions;
• suprasegmental autonomic disorders (vegetative-vascular dystonia);
• decreased ability to learn;
• delayed psychomotor and speech development in children;
• critical conditions of newborns with perinatal injuries of the nervous system;
• various forms of cerebral palsy.

Dosing regimen

The drug is administered intramuscularly.

For adults, the drug is prescribed at a dose of 10 mg 1 time per day for 10 days; children weighing less than 20 kg - at a dose of 0.5 mg / kg of body weight, with a body weight of more than 20 kg - at a dose of 10 mg per day for 10 days.

If necessary, repeat the course after 3-6 months.

Solution preparation rules

The contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution.

Side effect

No side effects have been reported. Possible individual hypersensitivity to the components of the drug.

Contraindications to the use of the drug CORTEKSIN®

• pregnancy;
• lactation period (breastfeeding);
• individual intolerance to the drug.

The use of the drug CORTEKSIN® during pregnancy and lactation

The drug is contraindicated for use during pregnancy due to the lack of data from clinical studies.

If necessary, the appointment of the drug during lactation should be discontinued. breast-feeding(due to lack of clinical trial data).

Overdose

Currently, cases of drug overdose have not been reported.

drug interaction

The drug interaction of the drug Cortexin® is not described.

Terms of dispensing from pharmacies

Terms and conditions of storage

List B. The drug should be stored in a dry, dark place at a temperature of 2° to 20°C. Shelf life - 3 years.

Cerebrolysin - official instructions for use:

Clinico-pharmacological group:

Nootropic drug

pharmachologic effect

Nootropic drug.

Cerebrolysin® contains low molecular weight biologically active neuropeptides that penetrate the BBB and directly enter the nerve cells. The drug has an organ-specific multimodal effect on the brain, i. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

Metabolic regulation: Cerebrolysin® increases the efficiency of aerobic energy metabolism in the brain, improves intracellular protein synthesis in the developing and aging brain.

Neuroprotective action: the drug protects neurons from the damaging effects of lactic acidosis, prevents the formation of free radicals, increases survival and prevents neuronal death under conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate).

Neurotrophic activity: Cerebrolysin® is the only nootropic peptidergic drug with proven neurotrophic activity similar to that of natural neuronal growth factors (NGF), but manifested under conditions of peripheral administration.

Functional neuromodulation: the drug has a positive effect on cognitive impairment, improves concentration, memory processes.

Pharmacokinetics

The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.

Indications for use of CEREBROLISIN®

• Alzheimer's disease;
• dementia syndrome of various origins;
• chronic cerebrovascular insufficiency;
• ischemic stroke;
• traumatic injuries of the brain and spinal cord;
• delay mental development in children;
• hyperactivity and attention deficit in children;
• endogenous depression resistant to antidepressants (as part of complex therapy).

Dosing regimen

The drug should be used parenterally. The dose and duration of use depend on the nature and severity of the disease, as well as the age of the patient. Perhaps a single administration of the drug at a dose of up to 50 ml, but it is more preferable to conduct a course of treatment.

To increase the effectiveness of treatment, repeated courses can be carried out as long as there is an improvement in the patient's condition due to treatment. After the first course, the frequency of injections can be reduced to 2 or 3 times a week.

Cerebrolysin® is used parenterally in the form of intramuscular injections (up to 5 ml) and intravenous injections (up to 10 ml). The drug in a dose of 10 ml to 50 ml is recommended to be administered only by slow intravenous infusion after dilution with standard infusion solutions. The duration of infusions is from 15 to 60 minutes.

After opening the ampoule, Cerebrolysin solution should be used immediately.

Side effect

Side effects are common (>1/100,<1/10); редко (>1/1000, <1/100); в отдельных случаях (>1/10 000, <1/1000); в единичных случаях (<1/10 000).

With excessively rapid administration: rarely - a feeling of heat, sweating, dizziness; in isolated cases - tachycardia or arrhythmia.

From the digestive system: rarely - loss of appetite, dyspepsia, diarrhea, constipation, nausea and vomiting.

From the side of the central nervous system and peripheral nervous system: rarely - agitation, manifested by aggressive behavior, confusion, insomnia; in isolated cases - large epileptic seizures, convulsions.

Allergic reactions: in rare cases - hypersensitivity reactions, manifested by headache, pain in the neck, limbs, lower back, shortness of breath, chills and a collaptoid state.

Local reactions: rarely - skin hyperemia, itching and burning at the injection site.

According to the results of clinical studies, the following side effects have been reported:

From the side of the cardiovascular system: in isolated cases - arterial hypertension, arterial hypotension.

From the side of the central nervous system and peripheral nervous system: in isolated cases - fatigue, tremor, depression, apathy, dizziness.

Other: in isolated cases - hyperventilation, flu-like symptoms (cough, runny nose, respiratory tract infections).

It should be borne in mind that some undesirable effects (excitation, arterial hypertension, arterial hypotension, lethargy, tremor, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and occurred equally in patients treated with Cerebrolysin® and in patients in the placebo group.

Contraindications for the use of CEREBROLISIN®

• acute renal failure;
• epileptic status;
• hypersensitivity to the drug.

Use of CEREBROLISIN® during pregnancy and lactation

Cerebrolysin® should be used with caution in the first trimester of pregnancy and during lactation.

The use of the drug during pregnancy and during breastfeeding is possible only if the intended benefit to the mother outweighs the potential risk to the fetus / newborn.

The results of experimental studies do not suggest that Cerebrolysin® has any teratogenic effect or has a toxic effect on the fetus. However, similar clinical studies have not been conducted.

Application for violations of kidney function

Contraindicated in acute renal failure.

special instructions

With excessively rapid injection, a feeling of heat, sweating, dizziness may occur. Therefore, the drug should be administered slowly.

The compatibility of the drug (for 24 hours at room temperature and lighting) with the following standard infusion solutions has been tested and confirmed: 0.9% sodium chloride solution, Ringer's solution, 5% dextrose (glucose) solution.

Simultaneous use of Cerebrolysin with vitamins and drugs that improve cardiac circulation is allowed, but these drugs should not be mixed in the same syringe with Cerebrolysin.

Cerebrolysin® and balanced amino acid solutions should not be mixed in the same solution for infusion.

Only Cerebrolysin Clear Solution should be used and only once.

Influence on the ability to drive vehicles and control mechanisms

Clinical trials have shown that Cerebrolysin® does not affect the ability to drive vehicles and use mechanisms.

Overdose

Currently, cases of overdose of the drug Cerebrolysin® have not been reported.

drug interaction

With the simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors, mutual enhancement of their action is possible. In such cases, it is recommended to reduce the dose of the antidepressant.

Pharmaceutical interaction

Cerebrolysin® is incompatible with solutions containing lipids and with solutions that change the pH of the medium (5.0-8.0).

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C.

The shelf life of the drug in ampoules is 5 years.

Cerebrolysin is a nootropic drug. It contains biologically active low molecular weight neuropeptides that can penetrate through the provision of regulation (metabolic), functional neuromodulation, neuroprotection and neurotrophic activity - these are the properties of Cerebrolysin. We will consider analogues of this medication in this article. If the patient wants to choose a replacement for Cerebrolysin, then he must definitely consult a doctor.

The nootropic agent "Cerebrolysin", its analogues have the same indications for use, namely:

• dementia syndrome (acquired dementia) of various origins;
• Alzheimer's disease;
• cerebrovascular insufficiency in a chronic form;
• ischemic stroke;
• hyperactivity, developmental delay (mental) and deficit (lack) of attention in children;
• traumatic injuries of the spinal cord and brain;
• depression endogenous, resistant (resistant) to antidepressants.

What effect does Cerebrolysin have on the body?

The drug "Cerebrolysin", its analogues have a multimodal effect on the human brain, namely:

• on the part of metabolic regulation: improves protein synthesis in the cells of the developing and aging brain, contributes to a significant increase in the efficiency of aerobic energy metabolism of the brain;
• neuroprotective action: prevents the formation of harmful free radicals and the death of neurons due to ischemia and hypoxia, protects neurons from the negative effects of lactic acidosis, significantly reduces the damaging effect of excitatory amino acids;
• provides functional neuromodulation: helps to improve concentration and memory processes, has a beneficial effect in various disorders of cognitive functions.

What side effects can the drug "Cerebrolysin" have?

Allergic reactions, angioedema or chills, fever. In isolated cases, the remedy "Cerebrolysin", its analogues can cause - confusion, aggressiveness, insomnia, apathy and depression. Rarely - headache, hand tremor, dizziness. Very rarely - convulsions and epileptic seizures; arterial hypotension and hypertension, heart pain, arrhythmia, palpitations; chest pain, hyperventilation; vomiting, nausea, constipation, dyspepsia; maculopapular rash, increased sweating, feeling hot, itching, redness of the skin, urticaria; flu-like symptoms, increased fatigue; burning and erythema at the injection site, pain in the limbs, neck, lower back.

Which drug is better: "Cerebrolysin" or "Cortexin"?

Both drugs belong to the same drug group, but Cortexin is a new generation drug. It does not have such shortcomings as the drug "Cerebrolysin". Advantages of the drug "Cortexin":

• the speed of the onset of the therapeutic effect, the economic benefit in the application;
• can be prescribed for regurgitation syndrome and convulsive syndrome (for the drug "Cerebrolysin" these conditions will be contraindications).
• can be used from the birth of a newborn in the acute period of the disease (while the drug "Cerebrolysin" only from the third week);

Which of the drugs to choose: "Cerebrolysate" or "Cerebrolysin"?

Means "Cerebrolysate" is an analogue of the drug "Cerebrolysin". They differ in price (the first is several times cheaper than the second). If you want to replace the drug "Cerebrolysate" with its analogue, you must first consult with your doctor in order to avoid complications.

The drug "Cerebrolysin": what other analogues are there?

These are the following means: Cytoflavin, Semax, Ebselen, Nootropil, Tanakan, Glycine, Instenon, Cinnarizin, Stugeron, Cebrilizin.

The drug "Cytoflavin" is a drug that improves metabolic processes in the brain. Available in tablets (round, red enteric-coated, biconvex) and as a solution for intravenous administration. Active ingredient: succinic acid, riboxin, nicotinamide and riboflavin mononucleotide.

The drug "Semax" is a drug with neurometabolic, neuroprotective, neurotrophic, nootropic and antioxidant effects. Developed by Soviet scientists, included in the list. It has a low risk of side effects.

The drug "Nootropil" is a drug with a pronounced positive effect on the metabolism of the brain. Available in the form of granules for children (preparing syrup), solution, syrup and tablets. The active ingredient in Nootropil is Piracetam.

The drug "Tanakan" is a herbal medicine that significantly improves peripheral and central blood circulation. Also, this medication improves the supply of glucose to the brain, helps to normalize the tone of veins and arteries, and prevents platelets from sticking together.

It should be noted that Cerebrolysin is the only peptidergic nootropic drug with proven neurotrophic activity, which is similar to the action of natural neuronal growth factors.