Is it possible to use terzhinan. Terzhinan side effects reviews

Terzhinan is a unique combined drug used for local treatment in gynecology. It has an anti-inflammatory, antimicrobial, antifungal, antiprotozoal effect, and also has a positive effect on the integrity of the vaginal mucosa, on the constancy of pH.

The effectiveness of this medication is determined by the substances that make up its composition, Terzhinan is prescribed for a variety of gynecological diseases. It contains components such as:

• Neomycin sulfate is a broad-spectrum antibiotic that belongs to the aminoglycoside group;
• Ternidazole is a substance whose action is aimed at the destruction of Trichomonas, as well as anaerobic microorganisms;
• Prednisolone is a component that has the strongest anti-inflammatory effect;
• Nystatin is a bactericidal antibiotic that neutralizes Candida microorganisms.

What does Terzhinan treat?

1. This medication helps to eliminate bacterial vaginitis - common gynecological diseases, manifested by abundant white discharge from the vagina.
2. It is used in the treatment of trichomonas and fungal vaginitis, as well as vaginitis caused by mixed infection.
3. Also, this medication is used as a prophylactic to prevent the development of various infections that may develop against the background of surgical interventions, before abortion or childbirth, on the eve of intrauterine examinations, and under other similar circumstances.

Remember that this drug, like any other drug, has contraindications for use - conditions in which this medication cannot be used. It is better to refuse treatment with Terzhinan suppositories if you have hypersensitivity to at least one of the components present in its composition.

Rules for use and dosage

If this drug is used incorrectly, if the indicated dosage is exceeded, various adverse reactions may occur, Terzhinan suppositories should be used a certain number of times. Among the side effects that occur during the use of this medication, the following conditions can be distinguished:

• allergic manifestations;
• burning or itching in the vaginal area.

As a rule, doctors recommend using one vaginal tablet once at bedtime. Having previously moistened in boiled water, the candle must be inserted deep into the vagina, and then lie down for 10-15 minutes. The average duration of continuous treatment is 10 days. Throughout the entire period of treatment, a medical specialist monitors the patient's condition and, if necessary, can increase the duration of treatment therapy. For example, when confirming mycosis, the doctor most often increases the duration of treatment to 20 days, regardless of the onset of menstruation.

The use of this drug during pregnancy, lactation

Doctors allow the use of Terzhinan during pregnancy, as well as during breastfeeding. The most appropriate and safe for the health of an unborn baby is the use of such vaginal tablets from the second trimester of pregnancy. In the first trimester, this medicine can only be used if the doctor sees an urgent need for treatment with this medication.

Special instructions:

• In the treatment of trichomoniasis and various vaginitis, both partners should be treated.
• Treatment should be continued even during menstruation.
• Drug interaction Terzhinan with other medicines has not been established, so this medication can be used with almost all medicines.

Terzhinan is a combined hormonal drug that is applied topically in gynecology. If used incorrectly, there may be cases of various adverse reactions, Terzhinan tablets from which should be used strictly according to the instructions, following the instructions of your doctor. If you doubt the need for treatment with this medication, check out this article-instruction. In it you will find all the necessary information regarding the nuances of using this medication, indications and contraindications for its use, and much more. Take care of yourself and be healthy!

Some of the women from time to time are faced with such an unpleasant phenomenon as genital infections. They harm the general health of a woman, and also disrupt the rhythm of their usual and fulfilling life. In the prevailing cases of this kind of infectious diseases require an integrated approach, for which today such a drug as Terzhinan (Terzhinan, Tergynan) is very actively used. This tool is available directly in the form of candles, as well as tablets for vaginal application. Produced by the French company Laboratories Bouchara-Recordati (Laboratoires Bouchara-Recordati).

Instructions for use Terzhinan

The drug, produced in the form of tablets and suppositories, is intended for the treatment of many diseases in women. As a rule, one candle is prescribed per day, which is recommended to be kept in water for about 30 seconds before use.

The drug, regardless of the form of release, is recommended to be administered before falling asleep, so that during prolonged sleep it has a longer effect. If the suppository must be applied during the daytime, then after the procedure it is recommended to lie down for at least 15 minutes. Sometimes treatment may involve the simultaneous use of both tablets and suppositories.

The course of treatment with the drug, as a rule, is 10 days. With complex mycoses, therapy should be extended up to 20 days. The drug can be used even during menstruation.

Tablets, like Terzhinan suppositories, are inserted into the vagina. No more than 1 tablet can be used per day, which is administered immediately before bedtime. This form of release of the drug is also suitable for the rehabilitation of the vagina before childbirth, abortion and before surgical operations in the vaginal area. For this, 1 tablet of the drug must be administered 2 hours before the procedure.

Among other things, the tablets of this drug are well suited for men who also have thrush. However, for some, this form of the drug turns out to be completely inconvenient to use - in such cases, attention should be paid to analogues produced in the form of an ointment or cream.

Terzhinan in the form of candles

Suppositories are a more common dosage form of the drug, when compared directly with tablets. They are intended for topical vaginal use. With the help of the described remedy, you can get rid of not only candidiasis, but also many other problems - Trichomonas, bacterial infections and inflammation processes. Due to this, candles are used for many diseases of the female reproductive system. In addition, Terzhinan in the form of suppositories acts quite gently, due to which the vaginal microflora remains unchanged. It should be noted that some drugs of similar action do not differ in this feature, and after their use, the microflora in the vagina is somewhat disturbed.

When a woman bears a child, she is very susceptible to the appearance of all kinds of diseases, including in the genitals. The use of the drug during pregnancy is not prohibited, however, it must occur under the strict supervision of a gynecologist. The most dangerous is the use of suppositories directly in the first trimester, but during the second and third there is no such restriction. Most often, Terzhinan is used during pregnancy to treat vaginitis, which is characterized by the parallel appearance of inflammatory processes on soft tissues, as well as bacteria and fungi.

It should be noted that when using the drug during pregnancy, you can not be afraid that it will harm the unborn child. It does not affect the fetus, and also cannot cause an overdose.

Terzhinan in the form of tablets

In addition to candles, the antifungal agent is also available in tablet form. Tablets for ease of use have an oblong shape, it is difficult to confuse them with another medicine, since there is a letter "T" on both sides.

The drug is available in a carton box, and the tablets themselves are contained in an aluminum blister (6 pieces).

Just like a suppository, the tablet should be held in a glass of water for 30 seconds before administration - so its action will begin much faster. The drug in the presented dosage form should be used at bedtime.

The described tablets are approved for use even during pregnancy and lactation.

Indications for Terzhinan's use

Tergynan- This is a drug that has a fairly wide spectrum of action. Therefore, it is very often prescribed for such diseases:

• Inflammatory processes in the vagina, the main cause of which is Trichomonas;
• Thrush, which has absolutely any stage;
• Vaginitis of bacterial origin;
• Mixed vaginitis;
• Mycoses;
• Colpitis;
• Sanitation of the vagina;
• Prevention of inflammatory diseases after childbirth, abortion and diagnostic manipulations.

Terzhinan is not suitable for the treatment of cystitis.

Price Terzhinan

Terzhinan is a rather expensive drug that can be bought at any pharmacy. It must be said that different forms of release of the drug have different costs, which must be taken into account directly during the selection and purchase of funds.

The purchase of Terzhinan should be carried out only after this drug is prescribed by a doctor based on the diagnosis. Otherwise, you can make a waste if, for example, the patient makes the wrong diagnosis on his own (some people self-medicate due to the lack of opportunity to visit a doctor).

Terzhinan's analogs

Many patients prefer to choose an analogue of Terzhinan - more affordable from a financial point of view, however, no less effective. Terzhinan can be called a unique drug, which is facilitated by all its components. Therefore, this remedy has no direct analogues, however, it is possible to choose a medicine that is close in action, which contains components identical to the original.

Most often, instead of Terzhinan, such means are chosen:

• Polygynax (Polygynax). This is a very effective drug, which is the closest substitute for Terzhinan. Polygynax has practically no side effects, and its composition is distinguished by several substances that are also found in the original product. The main difference of this drug is that it does not contain such a substance as ternidazole. Therefore, Polygynax is not suitable for the treatment of such an ailment of the female genital organs as trichomonas colpitis. Also Macedonian scientists Goran D, Vesna A, Adela S, Biljana TK, Snezana M in 2004 found out that Polygynax is effective for the treatment of fungal (fungal) vaginitis.
• Pimafucin. It refers directly to antifungal agents that are used to treat a variety of diseases. Pimafucin is convenient in that it is available in several dosage forms- suppositories, ointment and tablets. The advantage of this antifungal drug is that during therapy with its use, you can not give up sexual activity. Sometimes patients complain about the occurrence of Pimafucin side effects such as burning, nausea and vomiting (they usually appear in the first days of treatment).
• Meratin Combi (Meratin Combi). It has a pronounced therapeutic effect, which manifests itself within a short time. The active ingredients are ornidazole (ornidazol), as well as neomycin sulfate, nystatin and prednisolone. In addition to antimicrobial, Meratin Combi has a corticosteroid and antiseptic action. It comes directly in the form of vaginal tablets, which are effective in treating the predominant percentage of vaginitis. Due to the special composition, this remedy is often used directly for the sanitation of the vagina, which is performed before an abortion or childbirth. If we talk about such a detail as the cost of Meratin Combi, then it practically does not differ from Terzhinan. This substitute is highly not recommended for use in combination with other drugs, and especially with hormonal drugs.
• Clotrimazole. The tool is of synthetic origin and successfully fights against fungal diseases of the vagina. Clotrimazole has practically no side effects, with the exception of non-serious allergic manifestations. The drug has some contraindications, one of which is early pregnancy.

It should be noted that some Terzhinan substitutes are more effective. This can be explained by the fact that they have a much greater aggressiveness, and, accordingly, the likelihood of adverse reactions. It is for this reason that it is not recommended to replace the drug without the knowledge of your gynecologist.

Evidence of effectiveness, opinions of medical scientists

In the article by Moroz Vladimir Anatolyevich from the National Pharmaceutical University (Kharkiv), published in the scientific and practical journal “Dermatovenereology. Cosmetology. Sexopathology ”(2010), it is indicated that in certain nosologies the effectiveness of Terzhinan is 94.4%. In addition, the medical scientist writes that this combo has all the properties of 5-nitroimidazoles, but has no contraindications for topical use, since it does not have bioavailability in this case. This is the key "highlight" of the combination drug ternidazole-neomycin-nystatin (in detail the four components are disclosed below). The agent has a synergistic antimicrobial, antiprotozoal and fungicidal effect, without leading to a violation of the quantitative and qualitative composition of the normal vaginal biota in general. The use of Terzhinan is regulated, among other things, by orders of the Ministry of Health of Ukraine No. 286 of 06/07/2004 and No. 96 of 12/27/2007.

Pharmacologists Vitaly Iosifovich Mamchur (MD) and Sergey Nikolaevich Dronov (MD) in an article in the journal "Medical Aspects of Women's Health" (2015) describe some of the advantages of the combo remedy: compact elongated-flattened the form of a tablet that increases the area of ​​contact with the mucosa; smooth glossy surface and rounded edges that prevent irritation; preventing the growth of fungi, in particular, as a result of irrational antibiotic therapy; greater compliance (voluntary adherence to the prescribed regimen); the presence of 4 basic substances in the composition, which prevents polypharmacy (drug load).

Iraida Stepanovna Sidorova and Ekaterina Igorevna Borovkova in an article in a magazine
Russian Bulletin of an Obstetrician-Gynecologist (2007) conducted an experiment comparing Terzhinan, Neo-Penotran, Dalacin and Betadine®. Terzhinan provided a 98% cure rate along with Neo-Penotran. It also distinguished itself by the most prompt action, a positive effect on microcirculation.

Savicheva Alevtina Mikhailovna, Spasmodova Elena Vladimirovna in 2017 ("Journal of Obstetrics and Women's Diseases") conducted an in vitro test of the terzhinan agent on microorganisms such as Candida spp., Enterobacteriaceae, Atopobium vaginae, etc. The drug showed high efficiency against the dominant part of microbes.

Savicheva Alevtina Mikhailovna, Zakharevich Natalya Nikolaevna, Mikhnina E.A. from the Research Institute of Obstetrics and Gynecology. Otta, St. Petersburg, determined the effectiveness of the combo agent in 93.8% and 100% in vaginal candidiasis for non-pregnant and pregnant women, respectively.

In addition, on the Internet you can find a brochure of the Bouchara-Recordati Laboratories (Laboratoires Bouchara-Recordati), containing the results of Terzhinan's research by a number of scientists, including Novikova S.V., Levashova I.I., Logutova L.S., Leush S.S., Dzyubanchuk T.V., Dubossarskoy Z.M., Kokhanevich E.V., Konoplyanko V.V. etc.

Also, the study of the agent was carried out by Kalugina L.V., Tatarchuk T.F., Shakalo I.N., German D.G., Kuznetsova A.V., Kalugina L.V., Lipova E.V., Khrzayan R.S. ., Kuznetsova A.N., Illarionova E.A., Iskra A.I., Belousov E.A., Belousova O.V., Petrenko S.Yu., Popkova S.M. Dobrovolskaya L.M., Chichul N.S. Therefore, it can be considered highly studied.

Composition of Terzhinan

The effectiveness of the drug is achieved due to its special composition, which includes three antibiotics at once. This applies to any form of drug release. More specifically, the drug contains four of the following components:

• Ternidazole (Ternidazole, C7H12ClN3O3). This is an antibiotic of synthetic origin, which represents a group of nitroimidazoles. It is a derivative of imidazole. Effective only when applied topically. Ternidazole successfully fights various representatives of bacteria, in particular Gardnerella vaginalis, as well as protozoa.
• Neomycin (Neomycin, C23H46N6O13). It is a complex antibacterial substance and aminoglycoside, which has a bactericidal effect. It was discovered back in 1949 in the laboratory of the Jewish-Ukrainian-American biochemist and inventor Selman Abraham Waksman. This antibiotic fights staphylococci, streptococci and other infections in a short time, while it is powerless in the fight against fungi.
• Nystatin (C47H75NO17). It was discovered in 1950 by chemists Rachel Fuller Brown and Elizabeth Lee Hazen. It is also an antibiotic that fights fungi. It is the nystatin agent that is responsible for the treatment of genital candidiasis. It refers directly to polyene antibiotics, which means that nystatin is able to somewhat increase the overall permeability of those cells that are harmful.
• Prednisolone (C21H28O5). This substance is an analogue of hydrocortisone. It was discovered in the mid-fifties of the last century in the course of chemical experiments with Corynebacterium simplex (removal of the acetyl group). It is an effective hormone that is directly responsible for reducing inflammation during topical use. In addition, prednisone also performs an anti-allergic function.

Depending on the form of release of the drug, it also has auxiliary components that give the drug the form of a tablet / suppository.

Thanks to this composition, the cure of a disease occurs quite quickly. At the same time, the integrity of the vaginal mucosa does not become impaired, as well as pH.

Application features

Terzhinan is contraindicated in the first trimester of pregnancy, and its use is also prohibited at the age of less than 16 years. During the use of this drug, you should completely stop sexual activity. The main reason for this need is the likelihood of the destruction of the condom under the action of one of the components of the drug (nystatin).

Diseases such as vaginitis and trichomoniasis require simultaneous treatment not only for women, but also for men. The fact is that if one of the partners does not undergo the necessary course of treatment, then the other will definitely become infected again.

One of the possible side effects of the drug is dizziness. It is for this reason that it should not be used by those persons whose work is directly related to the management of road transport or other mechanism.

Patients who have other chronic diseases, during treatment with Terzhinan, you should carefully monitor your health. The presence of such diseases provides for a fairly frequent delivery of the necessary tests and special studies. This applies to such diseases:

• High blood pressure;
• Tuberculosis;
• Osteoporosis;
• Diabetes mellitus of any type;
• heart or liver failure;
• Epilepsy;
• myopathy;
• Glaucoma.

Combined preparation for local use in gynecology. It has an antimicrobial, anti-inflammatory, antiprotozoal, antifungal effect; ensures the integrity of the vaginal mucosa and the constancy of pH.

Ternidazole - an antifungal agent from the group of imidazole derivatives, reduces the synthesis of ergosterol (an integral part of the cell membrane), changes the structure and properties of the cell membrane. It has a trichomonacid effect, it is also active against anaerobic bacteria, in particular Gardnerella spp.

Side effects

• Feeling of itching, burning and irritation in the vagina;
• allergic reactions(rash, hives, skin itching, etc.).

Contraindications for use

Tablets (candles) Terzhinan: release form, composition, indications, instructions for use, dosages, contraindications, side effects - video

Analogues

Terzhinan's analogues are the following drugs:

• Vagisept vaginal suppositories;
• Vagiferon vaginal suppositories;
• Gynomax vaginal suppositories;
• Ginalgin vaginal tablets;
• Giterna vaginal tablets;
• Klion-D 100 vaginal tablets;
• Clomegel gel vaginal;
• Metrogyl Plus vaginal gel;
• Metromicon-Neo vaginal suppositories;
• Neo-Penotran, Neo-Penotran forte and Neo-Penotran forte L vaginal suppositories;
• Polygynax vaginal capsules;
• Polygynax Virgo emulsion for insertion into the vagina;
• Elzhina vaginal tablets.

Cheaper analogues of Terzhinan

• Vagisept - 209 - 230 rubles;
• Ginalgin - 230 - 300 rubles;
• Clomegel - 60 - 120 rubles;
• Metromicon-Neo - 300 - 400 rubles for 14 tablets.

What is better than Terzhinan?

Terzhinan is an effective drug, well suited to many women, so it is considered a "good" remedy. If any woman at this particular moment did not fit the drug, then you will have to try using analogues. And the analogue that turns out to be the most suitable and effective, and will be the best for this particular woman at the current time.

According to the reviews of doctors and women, Vagisept, Polygynax, Gaynomax and Elzhina are good analogues of Terzhinan. Therefore, if Terzhinan for some reason did not suit the woman or was not effective enough, then it is recommended to try these drugs, which are highly likely to be better.

Reviews about the drug

Also, women used Terzhinan before the treatment of cervical erosion ("cauterization") in order to eliminate the inflammatory process in the vagina and normalize the smear. In almost all cases, the drug was effective.

Negative reviews are usually associated with a burning sensation, irritation and itching that occurs at the beginning of therapy and disappears after 2 to 4 days. However, it is very difficult for some women to tolerate these symptoms, as a result of which they stop using Terzhinan and leave a negative review about the drug.

Combined local drug used in the field of gynecology is Terzhinan. Instructions for use recommends using the remedy for bacterial vaginitis, vaginal trichomoniasis, as well as fungal and mixed vaginitis. This medication has antibacterial, antiprotozoal, antifungal and anti-inflammatory effects.

Composition and form of release

A remedy is produced in the form of vaginal suppositories (tablets). In addition to the active ingredients, Terzhinan vaginal tablets include: wheat starch (Amylum tritici), colloidal silicon dioxide (Silicii dioxydum colloidale), sodium starch (type A; Natrii amylum), magnesium stearate (Magnesium stearate), lactose (Lactose).

Pharmacological properties

The active components of Terzhinan have an antibacterial, antiprotozoal, anti-inflammatory and antifungal effect due to its constituent components:

• Ternidazole, which is active against many anaerobic bacteria (in particular, Gardnerella spp.), has a pronounced trichomonacid effect.
• Nystatin is a highly active antifungal antibiotic (in relation to fungi of the genus Candida).
• Neomycin sulfate belongs to the group of broad-spectrum antibiotics (aminoglycoside group).
• Prednisolone has an anti-inflammatory effect.

This composition of the drug Terzhinan, instructions for use says this, ensures the integrity of the vaginal mucosa and a stable pH.

Medicine Terzhinan: what helps

The main indications for the use of Terzhinan are vaginitis, which are provoked by microorganisms sensitive to the action of the drug. Use the drug in the following situations:

• Bacterial vaginosis.
• bacterial vaginitis.
• Vaginitis caused by fungi of the genus Candida.
• Trichomoniasis of the vagina.
• Mixed vaginitis.

In addition, Terzhinan (according to medical specialists) is very effective for the prevention of vaginitis in the following cases:

• Before hysterography.
• Before and after the installation of the IUD and diathermocoagulation of the cervix.
• Before performing various gynecological operations.
• Before childbirth and abortion.

Terzhinan with thrush

Terzhinan is recommended for the treatment of women in whom thrush is accompanied by a suspicion of secondary inflammation or infection with a secondary microflora. In addition, the use of Terzhinan is resorted to in cases where the symptoms are so pronounced that they should be stopped as soon as possible.

In some cases, the drug is indicated as a substitute complex therapy if previous treatment with other antifungal agents was ineffective. Reviews of suppositories for thrush left by patients and practicing gynecologists suggest that Terzhinan successfully cures a fungal infection, without provoking the development of unwanted side reactions.

The use of Terzhinan suppositories for ureaplasmosis

Despite the fact that the active growth of ureaplasmosis is most often associated with malfunctions of the immune system, treatment with immunomodulatory medicines does not always lead to the desired result. In this situation, they resort to the appointment of special antibacterial agents or antibiotics.

Very often, with ureaplasma, doctors recommend Terzhinan, which acts on a wide range of pathogenic microorganisms and provides a pronounced anti-inflammatory effect. A valuable property of the drug is that, provoking the death of microbes and fungi, it does not violate the natural microflora of the vagina.

Contraindications

Terzhinan instructions for use prohibits the use only with individual intolerance to the drug. This is fraught with allergic reactions. In other cases, there are no contraindications.

Medicine Terzhinan: instructions for use

According to the indications, Terzhinan is prescribed in the amount of one vaginal tablet per day, usually at bedtime. The tablet must be kept in water for 20-30 seconds before insertion into the vagina. The average duration of the drug is ten days, but the course of therapy with Terzhinan, according to indications, can be extended up to 20 days.

Stop treatment with the drug during menstruation should not be. An overdose of the drug is unlikely, since Terzhinan, according to the instructions, does not have a high degree absorption into the bloodstream. According to indications, the remedy can be used during pregnancy and lactation.

Side effects

Terzhinan, instructions and reviews explain, quite rarely provokes side effects. Since suppositories are used topically, their constituent components are absorbed into the systemic circulation in very low concentrations. Therefore, in most of the reported cases, they provoked exclusively local reactions, which were expressed as:

• allergy symptoms;
• burning sensations;
• tingling;
• itching;
• soreness;
• irritation at the injection site.

Systemic effects during treatment with the drug occur in isolated cases. Possible reaction the use of glucocorticosteroids (and, in particular, prednisolone) is a slowdown in the healing of wounds and cracks, and in some patients, atrophic processes in the mucous membrane may occur.

Analogues

Many patients, having received a drug prescription from a doctor, are trying to find an analogue of Terzhinan cheaper. Currently, the medicine has no analogues. For women diagnosed with bacterial vaginosis or vaginitis, a number of drugs can be prescribed, for example: Neotrizol, Polygynax or Meratin Combi. Despite the fact that they are similar in action to Terzhinan, the latter is unique in its composition and ability to have a complex effect on inflammatory and infectious processes that affect the mucous membrane of the female external genital organs.

Price

The average price of Terzhinan candles in Ukraine is 156-170 UAH. How much do candles cost in Russia? The price of 10 Terzhinan tablets varies - from 366 to 410 rubles. You can buy candles in Belarus for 17.5 - 23 Belarusian rubles.

A drug with antibacterial, antiprotozoal, antifungal and anti-inflammatory action for local application in gynecology

Release form, composition and packaging

Vaginal tablets light yellow, with possible inclusions of darker or lighter shades, flat, oblong in shape, with chamfered edges and printed in the form of the letter "T" on both sides.

Excipients: wheat starch - 264 mg, lactose monohydrate - q.s. up to 1.2 g, colloidal silicon dioxide - 6 mg, magnesium stearate - 10 mg, sodium carboxymethyl starch - 48 mg.

6 pcs. - strips (1) - packs of cardboard.
10 pieces. - strips (1) - packs of cardboard.

pharmachologic effect

Combined preparation for local use in gynecology. It has an antimicrobial, anti-inflammatory, antiprotozoal, antifungal effect; ensures the integrity of the vaginal mucosa and the constancy of pH.

Ternidazole- an antifungal agent from the group of imidazole derivatives, reduces the synthesis of ergosterol (an integral part of the cell membrane), changes the structure and properties of the cell membrane. It has a trichomonacid effect, it is also active against anaerobic bacteria, in particular Gardnerella spp.

Neomycin- a broad-spectrum antibiotic from the group of aminoglycosides. It acts bactericidal against gram-positive (Staphylococcus, Streptococcus pneumoniae) and gram-negative (Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Proteus spp.) microorganisms; inactive against Streptococcus spp. Microbial resistance develops slowly and to a small extent.

Nystatin- an antifungal antibiotic from the group of polyenes, highly effective against yeast-like fungi of the genus Candida, changes the permeability of cell membranes and slows down their growth.

Prednisolone- dehydrated analogue of hydrocortisone, has a pronounced anti-inflammatory, anti-allergic, anti-exudative effect.

Pharmacokinetics

Data on the pharmacokinetics of the drug Terzhinan are not provided.

Indications

Treatment of vaginitis caused by microorganisms sensitive to the drug, including:

bacterial vaginitis;

Trichomoniasis of the vagina;

Vaginitis caused by fungi of the genus Candida;

Mixed vaginitis.

Prevention of urogenital infections / vaginitis, incl.

Terzhinan vaginal tablets are a topical preparation that is generally well tolerated. But this is if treatment is carried out according to all the rules: as prescribed by a doctor and under laboratory control. Otherwise (and many women use it for self-medication), side effects cannot be avoided.

Terzhinan vaginal tablets is a highly effective combined drug with a complex antibacterial, antifungal, antitrichomonas and anti-inflammatory action. Terzhinan vaginal tablets contain basic and auxiliary substances that, when interacting, create a complex effect of getting rid of infection, inflammation and preventing injury to the vaginal mucosa. Terzhinan includes antibacterial agent neomycin (broad-spectrum antibiotic), antifungal agent nystatin (an antifungal antibiotic), the antiprotozoal ternidazole, and the anti-inflammatory drug prednisone (a glucocorticoid hormone).

Manufacturer version

A conscientious manufacturer (“Bouchard-Recordati laboratory, France) after numerous laboratory and clinical tests (including pregnant women suffering from vaginitis of various origins) found that with the correct use of the drug, side effects can only be in the form of allergic reactions (in such If the drug is canceled) and in the form of local irritation of the mucous membranes, which are manifested by some increase in burning and itching and disappear after a while, therefore, do not require discontinuation of the drug.

Self-treatment

Prednisolone is generally a very dangerous drug, in this case, when taking terzhinan vaginal tablets, it is assumed that the body is protected from its side effects various drugs that kill the infection. But as soon as the drug ceases to be used, a decrease in immunity makes itself felt. Therefore, after treatment with terzhinan vaginal tablets, competent gynecologists always prescribe restorative treatment in the form of drugs that help restore the normal microflora of the vagina. It is the normal microflora of the vagina that can restore local immunity. The bacteria that it contains secrete lactic acid, which makes the environment in the vagina acidic and uncomfortable for opportunistic microflora. This helps to restore immunity over time.

If a gynecologist prescribes terzhinan vaginal tablets, then this automatically means correct application with laboratory control. It is absolutely contraindicated to be treated with Terzhinan blindly, on your own.

In contact with

Terzhinan is a complex drug produced in the form of vaginal suppositories (tablets), which are widely used in the treatment of gynecological diseases.

Flat-shaped tablets have a yellowish tint. On both sides there is the letter "T", which makes it possible to distinguish the original medicine from a fake.

The composition of the candles

The composition of the vaginal preparation Terzhinan includes such active ingredients:

• ternidazole;
• neomycin;
• nystatin;
• prednisolone.

These are the main ingredients. The composition also includes a number of auxiliary substances.

Each blister contains 6, 10 vaginal suppositories. You should know that the shelf life of the drug is 3 hours at room temperature. The drug is dispensed by prescription.

Candles Terzhinan 6, 10 have antimicrobial, antifungal, antiseptic, trichomonacid properties. Each main component of the drug affects certain infections in its own way.

Ternidazole fights Trichomonas, anaerobic microorganisms. Neomycin - antibiotic, which disrupts protein synthesis in the cells of pathogenic bacteria and contributes to the death of microbial cells. Corinobacteria, Listeria are sensitive to this substance. Sensitive to neomycin and Pseudomonas aeruginosa.

Nystatin is an antibiotic that destroys fungal cells. Fungi of the genus Candida and eukaryotes are sensitive to this substance.

Prednisolone is a substance that has anti-inflammatory, anti-allergic, anti-exudative effects.

Excipients affect the integrity of the epithelium, which can be impaired during infections and inflammatory processes. These substances also maintain the pH balance within the normal range.

When to use Terzhinan

Indications for candles Terzhinan 6, 10 are as follows: infectious diseases of the female genital organs and inflammation accompanying them.

The drug is prescribed in gynecology for:

• vaginitis, including trichomonas, caused by fungi of the genus Candida;
• colpitis, having a chronic, recurrent nature;
• vaginal dysbiosis;
• prevention of vaginitis for those women who need to be operated on in the pelvic area;
• before childbirth;
• surgical abortion;
• diathermocoagulation;
• examination of the uterine cavity, patency of the fallopian tubes and X-ray examination;
• installation of intrauterine contraceptives;
• antibiotic therapy;
• ureaplasmosis;
• thrush.

When Terzhinan is contraindicated

Contraindications to the drug Terzhinan is not so much:

1. Individual intolerance to the components of the drug.
2. Allergic reactions - in this case, the doctor should choose another drug.
3. Girls under 16 years of age.

Adverse reactions to the drug

Side effects from the use of Terzhinan 6, 10 vaginal suppositories are rare. There may be burning, tingling, itching, soreness at the injection site. These are local reactions.

In isolated cases, systemic reactions may occur. For example, the following may occur on prednisolone: ​​wounds and cracks heal more slowly, atrophic processes may occur in the mucous membranes.

Therapy with the drug does not affect the ability to drive a vehicle and conduct physical activity. As for an overdose of the drug, it is unlikely, since the adsorption of the drug is negligible, as is the penetration into the blood.

Instructions for use of the drug

Vaginal tablets should be inserted into the vagina, deeply. Once a day, use one tablet. Course of treatment 10 days.

Before the introduction of the tablet, it must be placed in water for half a minute or held in a wet hand for 2 minutes. After the introduction of the tablet in the daytime, it is necessary to lie down for 10 minutes. Enter vaginal suppositories best in the evening, before going to bed in a prone position. After the introduction of the suppository, there may be discharge that has a yellowish color. This is the norm.

The duration of the course of treatment with the drug can be 6-10 days, if the treatment is aimed at relieving inflammatory processes and normalizing the imbalance of microflora in the vagina. For preventive purposes, Terzhinan is prescribed for 6 days.

In the treatment of thrush with Terzhinan, the course of application extended to 20 days. After completion of treatment, after 3 days, you should be examined again, passing all necessary tests. If necessary, the course of treatment can be repeated.

Menstruation is not the reason for discontinuation of the drug. Anyway, daily dose must be agreed with the attending physician. Treatment will be effective if the sexual partner is treated at the same time. This will prevent the risk of re-infection.

Is it possible to use the drug during pregnancy

The instructions for the medicine indicate that it can be used during pregnancy. Terzhinan is not advisable to use in the 1st trimester of pregnancy. for up to 12 weeks. However, in some cases, the doctor may prescribe these vaginal tablets during this period of pregnancy. You should know that their use during pregnancy is possible only as directed by a doctor.

In addition, starting from the 2nd trimester of pregnancy, Terzhinan can be used in the presence of inflammatory processes. various etiologies. In the 3rd trimester of pregnancy, Terzhinan is prescribed to normalize the vaginal microflora, to restore the mucous membranes, epithelium, and also in case of infection. Terzhinan is also prescribed for the treatment of the birth canal in order to protect the baby from infection with candidiasis.

Active substances the drug does not have a negative effect on the fetus, since it practically does not enter the circulatory system. During breastfeeding, Terzhinan is not contraindicated, since none of its active components penetrate into breast milk mother.

Inflammatory processes and the use of Terzhinan

Candles Terzhinan 6, 10 have indications for vaginitis- a disease of the external female genital organs and the mucous membrane of the vagina, in which inflammatory processes appear caused by various pathogenic microorganisms.

It is impossible to start this disease, just like self-medication, since vaginitis can become chronic and give complications. Often vaginitis is caused by mixed infections: fungal and bacterial. For this reason, combined drugs are prescribed for their treatment, which include Terzhinan. The course of treatment for this disease is 10 days.

Features of the use of the drug

Before you start using Terzhinan, you should be aware of some of the features of using these vaginal tablets.

In the treatment of vaginitis, it is desirable to temporarily limit sexual activity. If a diagnosis of trichomoniasis is made, then conduct a comprehensive diagnosis. It is also desirable to start treatment of the sexual parterre.

The main components of the drug do not affect the structure nervous system and activity of the cerebral cortex.

What can be used after Terzhinan

Many doctors advise after a course of treatment with Terzhinan to put candles with lactobacilli and bifidobacteria, which will help speed up the restoration of microflora. For these purposes appoint:

• Wagisan;
• Bifidumbacterin;
• Acylac.

Also often prescribed capsules for oral Vagilak. This preparation contains strains of lactobacilli that penetrate from the intestines into the vagina. These strains take root easily. In order to restore the microflora, you can take probiotics. Restoring the intestinal microflora will speed up the recovery process in the genitals.

Terzhinan - effective drug in the treatment of gynecological diseases. He is able to quickly get rid of unpleasant symptoms and heal the disease. However, it can be used only with the recommendation of a doctor. Self-medication is unacceptable.

They help well from the infection, but then there is such discomfort that it is better to start treatment with ecofemin right away. Nexicon is more effective.

Candles Terzhinan are a combined preparation, which is characterized by the presence of antifungal and bactericidal properties.

Many users ask what Terzhinan candles are, what they help with.

With the help of this medication, you can get rid of anaerobic microorganisms, pyogenic bacteria, fungi, etc.

Due to the presence of a substance called ternidazole in the composition of this drug, it is used to produce a high-quality fight against Trichomonas. When using the drug, anaerobic microorganisms also die.

The destruction of protein synthesis in the cells of pathogenic microorganisms is carried out with the help of neomycin. This also contributes to the fact that the transcription of the genetic code is disrupted.

As a result, microbial cells die. Some people have a question, what are Terzhinan candles made of, what are they from? Given medication fully fights corynebacteria, Staphylococcus aureus, methicillin, listeria. All these microorganisms belong to the category of anaerobic bacteria.

As a result of the study of suppositories, the sensitivity of gram-negative bacteria to it was noticed. Pseudomonas aeruginosa is one of the bacteria that this medication destroys.

Terzhinan is characterized by the presence in its composition of nystatin, which is an antimycotic agent. That is why when using the drug, binding of nystatin and ergosterol, which is a component of the fungal cell membrane, is observed.

This leads to damage to the shell and to the death of fungi.
Sensitivity to this drug is also shown by fungi that belong to the category of the genus. With the help of Terjignan, you can fully fight against eukaryotes.

Some patients have a question, one hundred such candles Terzhinan, from what they are prescribed? Due to the presence of prenisolone in the preparation, it is characterized by the presence of anti-allergic, anti-inflammatory and anti-exudative action.

During the reception of this drug, there is no damage to the vaginal tissue of the epithelium. The pharmacokinetics of the drug has not been studied. This is due to the fact that Terzhinan has a low systemic absorption.

Candles Terzhinan are characterized by very good absorption, which allows them to be fully used for the treatment of various fungal and bacterial infectious diseases. More about Terzhinan will tell on the video:

Reasons for using Terzhinan

Thanks to unique composition of this medication, with its help, the fight against various diseases external genitalia of the female representatives, which are characterized by an infectious nature.

This medication is prescribed to patients in the presence of vaginitis, which occurs as a result of exposure to pyogenic microflora. Also, this drug is prescribed by doctors for recurrent colpitis, which belongs to the category of non-specific vaginitis.

With trichomonas vaginitis and vaginal dysbiosis, Terzhinan is also prescribed. If, as a result of the activity of fungi of the genus Candida, a female representative has vaginitis, then taking this medication is recommended by doctors.

With vaginitis, which have a mixed nature of origin, Terzhinan can also be used.

The drug is a prophylactic that is widely used to prevent the appearance of female representatives, who will later undergo various surgical interventions.

This medication is most often taken before the process of childbirth, abortion. If the patient is prescribed diathermocoagulation, then she needs to use suppositories not only before the procedure, but also after it.

Before conducting such a study as metrosalpinography, this drug is also used.

Terzhinan is used if the patient will be administered intrauterine. This medication in this case is used not only before the procedure, but also after it. With complications of antibiotic therapy, suppositories can also be used.

Candles Terzhinan are a broad-spectrum drug, which allows them to be used to treat various diseases.

Features of taking the drug

This medication is used when patients have:

• Vaganitov
• Vulvovaginitis
• , which are characterized by non-specific origin.

In order to prevent infections before operations, childbirth, candles are also used. Terzhinal is characterized by a high level of effectiveness and therefore it is widely used for preventive purposes.

Taking the drug is quite simple. Candles must be inserted into the vagina after taking hygiene procedures. This drug is taken for 10 days. At a time, a female representative must be inserted into the vagina one candle at a time.

In order for the suppository to soak, it is soaked in water for one minute before insertion into the vagina. After that, it should dry out a little.

When using this medication for the treatment of thrush, they must be used within 20 days. At the end of taking suppositories after three days, the patient must re-test, with the help of which the doctor can determine the effectiveness of the treatment.

The course of taking Te5rzhinan suppositories is determined depending on the type of disease and the individual characteristics of the female representative.

Treatment of any disease with the help of this medication should not be done independently, as this can lead to disastrous consequences. In this case, you must first consult a specialist.

Possibility of side effects and contraindications of Terzhinan

Like any other drug, this drug is characterized by the presence of actions. They happen on very rare occasions. The introduction of this drug is carried out locally.

That is why the absorption of the drug is carried out in the systemic circulation in a very low concentration.

In the reported cases of side effects of Terzhinan, the presence of allergic symptoms in the vaginal area and external genitalia is observed. In some cases, female representatives complained of a burning sensation during the use of this drug.

Also, during use, tingling may be observed. Discomfort for women during the use of the drug brings itching. During the use of suppositories, female representatives experienced irritation in the pelvic area.

A very rare side effect while taking this medication is poor wound healing. Atrophy of the mucous membranes of the vagina was observed in isolated cases of taking this medication.

In order to avoid side effects while taking this medication, it is necessary not to take it if there are pronounced contraindications.

Terzhinan is forbidden to be taken by women who have pronounced allergic reactions.

The use of the drug is carried out by female representatives, whose age is more than 16 years.

Terzhinan is a universal drug that is widely used to treat diseases in women. The drug is characterized by ease of use and high impact.

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