Aquadetrim (Vitamin D3). Aquadetrim vitamin D3 Aqueous solution of vitamin D3 instructions

Today, it would seem, we have almost forgotten about such a terrible disease as rickets. Humanity has been overwhelmed by cardiovascular and immune pathologies, and the “plague of the century” is called diabetes. Nevertheless, on the shelves of almost all pharmacy kiosks, you can find Aquadetrim. Why, with a decline in obvious manifestations of hypovitaminosis of cholecalciferol, this drug does not lose its relevance?

The functions of vitamin D3 are directly related to the regulation of phosphorus-calcium metabolism in the body. That is why all the pathologies caused by a lack of this vitamin lead to diseases of the muscular, cardiovascular, bone and endocrine systems of a person.

Deficiency in the body is directly related to hypovitaminosis vit. D3. Especially often this relationship is manifested in the softening and senile degeneration of bone tissue.

And also in people with low consumption of dairy products, nuts, sea fish and seasonal restriction in greenery. Vitamin-mineral imbalance has also been identified in the following cases:

• Osteoporosis, as well as age-related changes in bone mineral density.
• Violation of the functions of the parathyroid glands.
• Pathologies of the immune system.

The use of therapeutic doses of calcium-containing drugs provokes high mortality from cardiovascular diseases.

It was found that daily rate calcium, which is 1000 - 1500 mg, requires a mandatory combination with cholecalciferol in the amount of 800 IU per day.

The lack of vit. D3 also accompanies somatic diseases:

• Chronic hypertension and cardiovascular pathologies.
• Diabetes mellitus type II.
• chronic gastritis, peptic ulcer stomach and intestines, as well as other pathologies of the gastrointestinal tract. A history of cholecystitis increases the risk factor for hypovitaminosis.
• Pulmonary obstruction, tuberculosis.

With a lack of vit. D3 leads to tetanic muscle spasms and premature births. Provokes a violation of the formation of bone tissues of the fetus.

Composition and form of release Akvadetrim

Vit. D3 is unstable to UV radiation and is easily destroyed when exposed to air. Therefore, a dark glass bottle containing 10 ml of an aqueous solution of calciferol is equipped with a dosing pipette and a cap. This not only facilitates the dosage of the drug, but also protects it from oxidation.

From the point of view of compensating for the lack of cholecalciferol, dietary supplements containing at least 400 IU of the active substance have a vitamin value. 1 ml of a solution equivalent to 30 drops contains:

1. Vit. D3 - 15000 IU, 500 IU in 1 drop.
2. Excipients contribute to the stabilization of cholecalciferol and provide the possibility of its long-term storage. They also improve the taste and aroma properties of the drug. In addition, citric acid in bone tissue forms with calcium under the action of vit. D3 insoluble salts that promote bone mineralization.

• Macrogol glyceryl ricinoleate is a substance whose main component is castor oil.
• Citric acid - flavor and preservative E330, benzyl alcohol - flavor and preservative, sucrose - flavor and stabilizer, sodium hydrogen phosphate dodecahydrate - preservative E 339.
• Flavoring - anise essence.
• Purified water.

Indications for taking Akvadetrim

Necessary for activation of macrophage immune responses. Especially with mycosporic lesions of the lungs. Including tuberculosis and chronic obstruction.

To reduce the hyperfunction of the parathyroid glands.

Acquired hypovitaminosis D3 associated with malnutrition, rare exposure to the sun or peculiarities of national dress. Often leads to adenoma thyroid gland. It is also observed in liver diseases and lipid metabolism disorders such as celiac disease and cholestasis.

Prevention of rickets in children from 2 months to 2 years. The manifestations of this formidable disease are: softening of the bones, deformation of the skull, chest and shins, an increase in the abdomen, flabbiness of the muscles, a slowdown in the ossification of the fontanel and an increase in the period of teething. For (and older children) it is better to use an aqueous solution of vitamin Aquadetrim, as it is absorbed faster and better absorbed by the body than oil drops.

Dosage

With a daily requirement for vit. D3 in children - from 500 to 1000 IU and adults - 800 IU, Aquadetrim is recommended both prophylactically and for the correction of calcium phosphorus metabolism disorders:

Children from 4 weeks to 3 years prophylactically - 1 drop. If there is a risk of developing rickets - from 2 to 3 drops.

1 drop per day. With special instructions from the doctor - 2 drops from 28 weeks.

Postmenopausal period -1 or 2 drops.

Treatment of rickets and rickets-like conditions is carried out only under the supervision of the attending physician and depends on the severity of the disease.

Therapy vit. D3 is individual for each patient and requires biochemical control throughout the treatment.

Contraindications

Hypervitaminosis vit.D.

High levels of calcium in the blood and urine.

Violation of water-salt metabolism, including with a tendency to form calcareous kidney stones.

Chronic kidney failure and other disorders of the kidneys or liver.

Sarcoidosis and tuberculosis in the acute phase.

Intolerance to food additives of class "E".

Newborns up to 4 weeks.

Without special instructions from the doctor, you should refrain from taking Aquadetrim when:

Tendency to allergies.

Combination with diuretic thiazides.

Simultaneous reception with glycosides increases the toxicity of digitalis and the risk of cardiac arrhythmias.

Dangers of hypervitaminosis D3 during pregnancy and lactation.

The propensity of newborns to the rapid overgrowth of the fontanel.

Side effects

Overdose. Vitamin D3 is easily absorbed, entering the body as part of fatty milk products (cream, sour cream,), as well as egg yolks, and yeast. In addition to this, it is formed in the skin under the action of sunlight and accumulates. Therefore, uncontrolled intake of Aquadetrim can lead to hyperavitaminosis of cholecalciferol.

Symptoms: nausea, vomiting, loss of appetite and weight, thirst, increased daily diuresis and the appearance of protein in the urine, constipation, hypertension, excessive muscle tone and joint pain. From the NA side: headache, mental disorder, depression, insomnia.

Chronic overdose makes the bones brittle and brittle. Vessels, tissues and lungs lose their softness and elasticity during the formation of lime deposits. Ataxia, stupor, inflammatory keratids, cataracts, papilledema, and urolithiasis are possible.

Interaction with other drugs

Suppressed by phosphates and calcium.

Decreased effectiveness when taken simultaneously with cholestyramine, antiepileptic drugs and rifampicin.

Combination with digitalis preparations and thiosides is life threatening.

Aquadetrim is equivalent to dietary supplements. It is believed that such funds do not require the advice of specialists. However, numerous nuances of Aquadetrim's effect on the body urgently require a doctor's consultation.

The average price for vitamin D3 aquadetrim in Moscow pharmacies is about 195 rubles. But, in online pharmacies you can find cheaper (from 125 rubles).

Reviews about Akvadetrim

Pavel S. The summer turned out to be rainy, and my daughter is at the age when children grow up. Heard enough of the doctor's warnings about rickets and decided to insure himself with Aquadetrim. It wouldn't hurt to do it myself either. Before meeting Aquadetrim, he considered everything side effects empty talk. To be honest, I didn't even look at the abstract. They said that the vitamin is good, period. Daughter sprinkled immediately, and me - a week later. I sinned on fruits, shampoo and powder, but it turned out that the damned drug was to blame. The auxiliary composition is such that it is easier to drink the solvent. And this is what doctors prescribe for children! The Poles don't care what they sell us, but children are not a field for experimentation.

Tatiana B. 24 The reason for the appointment of Akvadetrim to my daughter is rickets 2 of the subacute course, the peak period. For a number of reasons, the child was born severely premature. Instructions for the use of vitamin D3 Aquadetrim and reviews on the Internet terrified me. But is allergy so terrible compared to rickets? Moreover, the oil-based vitamin was not suitable for us due to problems with the intestines. I can understand parents canceling Aquadetrim because of the backlash. Their children were prescribed the drug for prophylactic purposes. For us, he was a real lifesaver.

Kuzmin S.E., Dr. med. Sciences. The pathophysiological significance of hypovitaminosis of cholecalciferol in the anamnesis of somatic and cardiovascular diseases is enormous. Application in clinical practice of combination therapy of calcium-containing drugs with Aquadetrim in daily dose at least 800 IU recorded a positive trend. I would also like to note the preventive role of Akvadetrim in case of the threat of osteoporotic fractures and other disorders of bone tissue mineralization.

Smirnova E. N., pediatrician. Rickets in children does not pose an immediate threat to life, but increases mortality from concomitant diseases. It is rickets who are difficult to tolerate pneumonia, measles and whooping cough. Often hypovitaminosis D3 leads to the development of anemia, pneumonia, pathologies of the liver and spleen.

Newborns receive the necessary substances with mother's milk. Seasonal solar activity plays a huge role in this. Therefore, the risk group is made up of artificial children and children born in the autumn-winter season.

Rickets is a disease of rapid growth.

The needs of a growing organism for phosphorus, calcium and cholecalciferol are not satisfied by their delivery system.

Aquadetrim showed excellent results in the prevention and treatment of rickets. Its use allows you to normalize the functions of both a number of systems and organs, and the whole organism as a whole. After all, despite the strong opinion about the predominance of musculoskeletal symptoms of rickets, its first manifestations are associated with the nervous system. Anxiety, tearfulness, the appearance of diaper rash due to excessive sweating can be a signal for the appointment of Akvadetrim. At the same time, it is important to prevent the outbreak of the disease.

Features of the metabolism of cholecalciferol and its close relationship with mineral metabolism make Aquadetrim a therapeutic drug rather than a dietary supplement. Too huge connection vit. D3 with the nervous, endocrine, muscular and cardiovascular systems of the body.

In general, Aquadetrim is an excellent prophylactic and therapeutic agent in the presence of factors that reduce the effectiveness of oil solutions of vit. D3.

The allergenic composition of the excipients of Aquadetrim is associated with the fat-soluble nature of its active ingredient. It is worth noting that chem. class E substances are officially used not only in pharmacology. Most modern products are “rich” in more serious additives, but they do not cause complaints from consumers.

The drug Complivit® Aqua D3 (COMPLIVIT® AQUA D3) is a vitamin D3 that acts as a regulator of calcium-phosphorus metabolism in the body. Instructions for use explains the purpose of the drug.

According to the instructions for use, the drug Aqua D3 has a composition of the following components:

• fat-soluble vitamin cholecalciferol;
• polyethylene glycol;
• fatty ester recinolein;
• cane sugar;
• aqueous salt of sodium crystal hydrate;
• tribasic carboxylic acid;
• isoestragol;
• phenylcarbinol;
• medical sterile liquid.

Release form

Aqua D3 has the appearance of a colorless liquid with a pearly sheen, as well as a specific smell of vitamin D3. The product is packaged in a dark glass container with a preparation volume of 10 ml. It closes with a plastic dropper cap. Packed in a thick paper box.

Pharmacodynamics

The drug exhibits an antirachitic effect, and is also the main metabolite of calcium in the human body. The properties of the drug are based on the regulation of the process of proper growth of the skeletal system.

The main substance of the drug Aqua D3 affects the transport of calcium and phosphorus through the intestines, is active in delivering minerals to the skeletal system of the body, and contributes to the process of regulating the release of phosphorus and calcium by the urinary system.

Helps the proper functioning of the myocardium, affects the production of platelets. The main substance of the drug is cholecalciferol, which is necessary for the body for the normal functioning of the parathyroid gland and the immune system.

Indications for use

• vitamin prophylaxis D3;
• abnormal development of the skeletal system, as a result of a lack of calcium;
• metabolic disease;
• systemic disease of insufficiency of minerals in the bone system;
• decreased bone density;
• absorption deficiency syndrome;
• long-term pathologies thin department intestines;
• primary sclerosing cholangitis;
• postoperative period on the organs of the digestive system.

How safe is the drug for children?

Aqua D3, according to the description in the instructions for use, should be used in children from the 28th day of life. With caution, it is necessary to prescribe the remedy to infants if there is a predisposition to early overgrowth of the membranes connecting the bones of the skull.

When prescribing the drug to children under the age of 1 year, the amount of vitamin D3 in the blood should be constantly monitored so that there is no overdose (a feature of the child's body - the need for the vitamin depends on age and is constantly changing).

Instructions for use

Aqua D3 (instruction for use describes how to use the drug for various pathologies) must be used not only for treatment, but also for the prevention of vitamin D3 deficiency in the body.

For adults

Vitamin prophylaxis D3:

• with insufficient absorption syndrome, problems with the small intestine, primary sclerosing cholangitis and in the postoperative period on the organs of the digestive system, Aqua D3 should be used up to 10 drops per day.

Treatment:

• all of the above pathologies, as well as the period of menopause, should be treated with increased doses of Aqua D3 - more than 10 drops per day, but under strict control and as directed by a gastroenterologist;
• systemic pathology of mineral deficiency in the bone system, it is necessary to use the drug in courses of 6-10 drops daily. Month to drink - 30 days rest;
• blood calcium levels should be checked long-term use facilities.

For children

Prevention of abnormal bone development:

• children who were born on time should be given 1 drop of the drug daily;
• those born before the 38th week of pregnancy - 2 drops from the 28th birthday to 12 months.

Treatment of children:

• with abnormal bone development and softening of bone tissue, you should drink 2-4 drops once a day. Duration of treatment: 24 months;
• with maintenance therapy of systemic calcium deficiency, the body needs to take 2-4 drops - once a day, constantly. Under the control of blood counts;
• congenital insufficiency of calcium absorption, you need to drink 1-2 drops of the drug - once a day, constantly.

Use in elderly patients

In old age, before prescribing Aqua D3, a biochemical analysis of the amount of creatinine in the blood should be done, due to a possible violation of the kidneys at this age.

In the case of normal test results, dosage adjustments for patients of the elderly age group are not required.

Conversely, this vitamin is necessary for people at the age - when the amount of bone mass decreases and the bones become fragile. The use of the drug Aqua D3 will help to cope with muscle weakness, bone pain, affect the level of blood pressure, improve the psycho-emotional state.

Aquadetrim for newborns

Akvadetrim is a drug with the main active substance cholecalciferol. The drug can be used as a means to prevent abnormal development of the skeleton and bones, as well as for therapeutic purposes.

You should know that at different times of the year the amount of the drug should be changed, due to an increase or decrease in solar activity, which contributes to the production of vitamin D. In autumn and winter, when solar activity is not high, the amount of the drug should be increased (in accordance with the prescription of a pediatrician ).

In order to prevent, in this period of time of the year should be given to infants (born on time) - 1 drop of medication per day. For children born before the 38th week of pregnancy, the dose of the drug should be increased to 2 drops - once a day. The medicine is diluted with milk or liquid for drinking.

For the treatment of vitamin D3 deficiency, which affected the development of the skeleton, one should use from 4-5 drops of the drug (with simple forms of the disease), up to 10 drops once a day - with a complex course of rickets. Drops must be added to milk or water.

The course of treatment, as a rule, lasts from 30 days to 45 days, unless the pediatrician prescribes otherwise. In spring and summer, when there is an increase in ultraviolet production, the dose of the drug must be reduced.

During pregnancy and lactation

The drug Akvadetrim should be taken by pregnant women during the entire period of pregnancy. In the warm period of the year - spring, summer, you should drink 1 drop a day or 2 drops medicinal product starting use after 30 weeks of pregnancy. In winter and autumn, the dosage should be increased by 1 drop.

In case of impaired renal function

Aquadetrim is a drug whose main substance is cholecalciferol. Vitamin D3 stimulates the production of calcium and phosphorus in the body. With excessive accumulation of these minerals, crystals can form in the kidneys, which in turn will lead to urolithiasis.

It should be borne in mind that Aquadetrim increases the intake of vitamin D3 in the body and, as a result, the amount of calcium and phosphorus increases. Therefore, patients with impaired renal function should not use the drug.

Contraindications

The drug Aquadetrim, like any pharmacological agent, has contraindications for use:

• increased amount of calcium salts in the blood;
• vitamin D intoxication;
• increased calcium content in urine;
• uric acid diathesis;
• nephrolithiasis or the formation of stones in the urinary system;
• Besnier-Beck-Schaumann disease, which is characterized by the formation of calcifications in the visceral organs;
• an acute decrease in kidney function, which entails a violation of the body's metabolic processes;
• long-term progressive pathology of the kidneys, with a decrease in excretory and metabolic functions;
• violation of all kidney functions;
• tuberculosis with the ability to cough up a pathological bacillus into the environment;
• children up to 28 days from birth;
• allergic reactions in history;
• personal intolerance to vitamin D3;
• allergy to phenylcarbinol;

Side effects

The pharmacological preparation Akvadetrim can have a negative effect on the body and manifest itself in the form of side symptoms.

Digestive system:

• anorexia;
• vomiting reflex;
• dryness in the mouth;
• dyspeptic manifestations in the form of a fixed stool;
• lack of desire to eat;

Nervous system:

• migraine headache;
• astheno-neurotic syndrome;
• manifestations of vegetative-vascular dystonia;

Mind:

• loss of strength as a result of a mental disorder;
• mood disorders;

Urinary system:

• increased calcium and phosphorus in the blood and urine;
• the formation of calcium crystals;
• an increase in the amount of urine;
• deposition of calcium salts in visceral organs;

Skin covering:

• immunological disorders in the form of itching;
• nettle rash;

Musculoskeletal system:

• muscle pain;
• pain in the bones and joints;
• weight loss.

Overdose

When using a large amount of Aquadetrim, symptoms of an overdose or poisoning may appear:

• prostration;
• lack of desire to eat;
• vomiting reflex;
• difficult defecation or its absence;
• dryness in the mouth;
• increased need for drinking;
• increased excretion of urine by the kidneys;
• inflammation of the stomach with reduced production of hydrochloric acid;
• loose stool;
• spasmodic pain in the intestines;
• increased work of sweat glands;
• unsteadiness of gait;
• interruptions in the work of the heart or arrhythmia;
• pain in skeletal muscles;
• migraine headaches;
• depressed mental state;
• prostration;
• motor disorders;
• lethargy, immobility;
• severe weight loss;
• excretion of protein in the urine;
• the appearance of red blood cells in the urine;
• decrease in the amount of potassium in the body;
• low specific gravity of urine;
• violation of urine diversion, which is expressed in the fact that the entire daily volume of urine is excreted at night;
• hypertension;
• degeneration of the cornea of ​​the eyes;
• papilledema;
• inflammation of the iris of the eyeball;
• kidney stones of different chemical composition;
• liming of the renal tubules;
• deposition of calcium salts in the muscles of the body;
• calcification of the vascular system and visceral organs;
• violation of the outflow of bile into the duodenum.

If you experience any symptoms of an overdose, you must:

• cancel drug treatment;
• assign strict rest;
• diet food with a minimum content of oxalates;
• drinking large amounts of water;
• use drugs with a laxative effect on the intestines;
• at increased amount calcium in the blood serum, a large volume of isotonic sodium chloride solution should be injected intravenously;
• inject diuretics;
• the use of ethacrynic acid;
• intravenous drip of steroid hormones;
• drugs based on the hormone thyrocalcitonin;
• in very severe cases, extrarenal blood purification.

The drug has no antidote.

special instructions

To avoid the negative consequences of therapy with the drug Akvadetrim, you need to listen to special instructions:

• monitor the amount of the drug used;
• during therapy with Aquadetrim, it is necessary to consider how much calcium enters the body with the food eaten;
• you should be aware that large amounts of the drug will lead to hypervitaminosis D3;
• it is impossible to combine the intake of cholecalciferol with calcium preparations;
• the drug should not be used for rare hereditary disease, in which the level of parathyroid hormone is increased;
• should be done periodically general analysis urine and blood.

Interaction with other drugs

When using Aquadetrim, you should be aware of the interaction of the drug with other drugs.

• The use of Akvadetrim with drugs from the group of hydantoin derivatives reduces the absorption of cholecalciferol.
• The joint use of the drug with natriuretic drugs increases the manifestation of elevated calcium in the blood.
• The use of cholecalciferol with medicines of plant origin, which have an antiarrhythmic effect, can, on the contrary, cause an increase in arrhythmia.
• The use of Aquadetrin or Aqua D3 with proton pump medications may increase magnesium levels in patients with renal insufficiency.
• The combined use of cholecalciferol with antifungal agents from the imidazole class can reduce D3 biosynthesis.
• The use of several types of drugs with the same constituent parts may cause drug poisoning.
• The use of vitamin D3 and statins can lead to a decrease in the output of cholecalciferol and other fat-soluble substances from the body.

Storage conditions and shelf life

Aqua D3 (instruction for use describes how to store the drug), like Aquadetrin, should be stored out of the reach of children and sunlight. The drug must be stored at a temperature of 14 degrees to 24 degrees Celsius.

Medication cost

The drug Aqua D3 and Aquadetrin are prescription drugs (as described in the instructions for use). But in reality, drugs can be purchased at any pharmacy without a doctor's prescription. The cost of drugs: Aquadetrin can be purchased at a pharmacy network at a price of 170 rubles. up to 210 rubles The price of Aqua D3 varies from 140 rubles. up to 190 rubles

Analogues

Aqua D3 and Aquadetrim are analogues, which in turn have preparations similar in composition and action - this is not described in the instructions for use.

Vigantol solution:

• the composition of the drug includes cholecalciferol, saturated fat bound to a glycerol base;
• available as a clear, lemon-colored thick liquid;
• the product is packaged in a container made of colored glass, with a plastic dispenser, a dropper and a lid, with a volume of 10 ml. The tool is packed in a box of thick paper;
• It is used as a prophylactic agent for calcium and phosphorus deficiency, as well as for the treatment of conditions with a lack of D3.

Koledan - drops for oral use:

• Koledan consists of cholecalciferol, acylglycerol, vegetable oil from castor bean, cane sugar, weak tribasic acid, phenylcarbinol, fruit flavor, orthophosphoric acid sodium salt, medical sterile liquid;
• the drug has the appearance of a clear liquid, with a lemon tint and a pleasant fruity odor;
• Koledan oral drops are packaged in a colored glass bottle, 10 ml each. It has a plastic dropper dispenser and a lid. Each bottle is packed in a thick paper box;
• the drug must be used to compensate for the lack of cholecalciferol in the body, as well as the treatment of pathologies accompanied by a lack of a vitamin-mineral complex.

Medicine Plivit:

• Drops consist of vitamin D3, para-hydroxybenzoic acid food supplement, ionol food supplement, ethylene glycol polymer, macrogol, organic fatty compound, weak tribasic acid, orthophosphoric acid sodium salt, medical sterile liquid;
• the drug is available in the form of oral, colorless, and slightly cloudy drops;
• the product is packaged in a colored glass bottle with a plastic cap and a dropper dispenser, 10 ml in 1 bottle. Placed in a thick paper box;
• a medicine with anti-rachitic action, as well as a prophylactic agent for D3 deficiency in the body.

Tridevit:

• the composition of the drug includes cholecalciferol, vitamin E, essential oil citrus fruits, sodium salt and oleic acid, refined oil from European olive fruits;
• the drug has the appearance of oily, with a yellowish tint and the smell of citrus drops;
• Tridevit is packaged in colored glass bottles with a plastic cap. The bottle is packed in a box of thick paper;
• the drug regulates the processes of calcium and phosphorus metabolism in the body, is a preventive and therapeutic anti-rachitic agent.

Videin tablets:

• the main composition of the tablets is cholecalciferol, as well as cane sugar, stearic acid with calcium, a water-soluble polymer;
• tablets have the shape of a flat cylinder, milky, with brown dots;
• the drug is packaged in 10 tablets in 1 plate, 5 pcs. in a thick paper box;
• the drug Videin takes part in the metabolism of the visceral system of the body and is used in pathologies of the musculoskeletal system.

Opinions and feedback on the effectiveness of the tool

Opinions on the Internet about the drugs Aqua D3 and Aquadetrin are almost the same, both in adult patients and in parents whose children took the drugs. From the feedback of people - this is good medicines, which are affordable and effective in pathologies associated with vitamin D3 deficiency.

The pharmacological agent Aqua D3, from patient reviews, is indispensable in the treatment of diseases accompanied by a lack of cholecalciferol - which is also written in the instructions for use.

Video about the drug Aqua D3, its effectiveness and rules of use

What is vitamin D3 responsible for?

Instructions for use Akvadetrim:

Aquadetrim for newborns is a drug for regulating calcium-phosphorus metabolism in a child's body. It is used in newborns, starting from 4 weeks of age.

Produced by the Polish company - manufacturer MEDANA PHARMA.

From pharmacies, it is freely available, without a medical prescription.

Dosage form

The drug is available in the form of drops for oral administration, 15000 IU / ml.

The volume of the bottle is 10 ml, the glass bottle is equipped with a soft and comfortable stopper-dropper and a plastic cap with a first opening control system. A bottle and an instruction leaflet are packed in a cardboard box.

Description and composition

Aquadetrim drops are a colorless liquid with a slight anise flavor.

1 ml of the drug contains active ingredients:

• Colecalciferol (vitamin D3) in the amount of 15,000 IU.

Sucrose, anise flavor in the form of an essence, gasoline alcohol, macrogol glyceryl ricinoleate, citric acid, hydrogen phosphate dodecahydrate, purified distilled water are present as complementary components.

1 ml of solution is measured in 30 drops.

Pharmacological group

The drug is a regulator of calcium-phosphorus metabolism. pharmachologic effect due to the pronounced antirachitic effect of vitamin D3.

The function of vitamin D3 is the process of regulating the absorption of calcium and phosphate in the body of a child, for the full growth and development of bone and muscle tissue.

Vitamin D, which is produced in human skin under the influence of sunlight, is identical to vitamin D3, which is part of the drops. Compared to vitamin D2, vitamin D3 is much more active, almost 25%. Colecalciferol has a great influence on the function of absorption of phosphates and calcium ions from small intestine, their excretion from the body, for the full delivery of mineral components and salts, calcification of the skeletal system.

Correct and full functioning bone skeleton and muscle tissue of the child directly depends on the concentration of calcium ions in the bloodstream. The level of this element also controls the function of the heart muscle, promotes neural conduction of excitation, and regulates blood clotting. Also, colcalciferol is indispensable for the functioning of the thyroid and endocrine glands, maintaining the body's natural immune defenses, and regulating the production of lymphokines.

If the process of absorption of vitamin D from the intestine is disturbed in the child's body, or there is a calcium deficiency, during the period of intensive development and growth of the body, these factors can provoke development. Pregnant women may suffer from symptoms of tetany, and after delivery, the newborn will have a lack of bone calcification. Such consequences can be caused by insufficient amount of sunlight, as well as insufficient intake of vitamin D in the body with food.

Pharmacokinetic properties

An aqueous solution of Aquadetrim drops is better absorbed by the body than oil-based solutions, since premature babies have not yet formed the full formation of bile and its entry into the intestines. The absorption of oily solutions in this case will be difficult.

After taking the drops inside, colcalciferol is absorbed in the child in the small intestine. Metabolized by the liver and kidney system. In case of renal insufficiency, the half-life of colecalciferol may increase from 1-2 to 4-5 days. Colecalciferol is excreted from the body with the help of the intestines and kidneys.

In lactating women, the drug passes into breast milk.

Indications for use

The drug is prescribed for the following indications:

• prevention and treatment of insufficient amounts of vitamin D in the body;
• prevention and therapy and similar pathologies;
• tetany, which developed as a result of hypocalcemia;
• osteomalacia and other pathologies of the skeletal system (hypoparathyroidism and pseudohypoparothyroidism);
• complex therapy osteoporosis, including that developed in women during menopause.

The use of drops in infants and pregnant women is possible after consulting a doctor and prescribing adequate dosages.

Contraindications

Drops are approved for use in newborns, starting from 4 weeks of age. Contraindications for admission are:

• hypersensitivity to one of the active ingredients of the drug;
• group D hypervitaminosis;
• hypercalcemia;
• hypercalciuria;
• urolithiasis disease;
• pathologies of the liver and renal system, as in chronic form, and in the acute stage;
• kidney failure;
• pulmonary tuberculosis in active form;
• sarcoidosis.

With extreme caution, you need to use the drug while taking thiazides and glycosides, during the period of bearing a child and breastfeeding, drops are used only after the doctor's permission. Also, infants prone to premature overgrowth of fontanelles require careful use of the medicine.

Use during pregnancy and breastfeeding

The use of vitamin D3 preparations during the period of bearing a child should be carried out under strict medical supervision, in order to avoid a teratogenic effect and overdose - the dose should not exceed 600 IU per day.

In lactating women, taking drops in higher doses can lead to the development of an overdose of vitamin D in a child.

Dosage and administration

Aquadetrim drops are intended for oral administration. For newborns and infants, the drug is given diluted in one spoonful of liquid. 1 drop contains approximately 500 IU of vitamin D3.

The dosage of the drug is usually recommended by the doctor, according to the instructions for use, the drug should be taken as follows:

• as a preventive measure for full-term infants, 500-1000 IU of the drug per day is recommended, provided there is enough sunlight, proper care and diet - this dosage should be followed until the child is 2-3 years of age;
• as a preventive measure for premature infants, twins and children growing up in unfavorable environmental and living conditions, it is recommended to take 1000-1500 IU of the drug per day, which is 2-3 drops (in summer, you can reduce the dose to 1-2 drops) - this regimen dosing must be observed until the child reaches 2–3 years of age;
• as a preventive measure, pregnant women are recommended 500 IU of the drug per knock throughout the entire period of bearing a child, or you can start taking drops from week 28 to 1000 IU per day;
• during menopause, women are recommended to take 500-1000 IU of the drug per day.

• - 2000-5000 IU of the drug daily, the course of treatment is from 4 to 6 weeks (or recommended by the doctor, depending on the symptoms and severity of the pathology). You need to start taking 2000 IU per day, gradually increasing the dose to 5000 IU after 5-6 days - subject to good tolerance and normal levels of calcium, phosphorus and alkaline phosphates in the blood plasma. If necessary, after a week break, the course of therapy is repeated until persistent therapeutic effect. After achieving positive results, it is sufficient to take a daily prophylactic dose of 500-1500 IU per day;
• rickets-like conditions - 20000-30000 IU per day, under the supervision of a physician and depending on the patient's age, weight and severity of the disease. The course of therapy with the drug is from 4 to 6 weeks, with the obligatory process of monitoring the parameters of the biochemical composition of blood and urine;
• osteoporosis during menopause complex treatment) - 500-1000 IU of the drug per day.

When prescribing an appropriate dosage of drops to children, the doctor is guided by the weight, age, living conditions, care and nutrition of the child.

Side effects

During the trials of the drug, the following possible side effects were noted:

• symptoms of excessive intake of vitamin D3 in the body - loss of appetite, nausea up to, weakness;
• headaches, muscle and joint spasm;
• mental disorders - the development of agitation or depressive states;
• weight loss;
• dry mouth;
• increase in body temperature;
• sleep disturbance;
• increased excretion of calcium ions in the urine;
• calcification of the renal system, blood vessels and lungs;
• in the urine - protein, hyaline casts, leukocytosis.

In the event of the development of such symptoms, you should immediately inform the doctor about this, in case of an overdose of vitamin D, preparations containing cholecalciferol are canceled, the intake of calcium into the body is limited.

Cross interaction

Simultaneous administration of Aquadetrim with antiepileptic drugs reduces the absorption of vitamin D in the intestine.

Thiazides and diuretics increase the risk of hypercalcemia.

With the simultaneous use of drops with cardiac glycosides, their toxic effect increases, which is fraught with a violation of the heart rhythm.

special instructions

During prophylactic and therapeutic administration of Aquadetrim, all sources of vitamin D intake into the body must be taken into account in order to avoid overdose and the development of chronic hypervitaminosis D.

The appointment of drops by a doctor for infants should be carried out taking into account his daily requirement for vitamin D, while monthly monitoring of the state of the child's skeletal system and the study of laboratory tests are mandatory, at least in the first months of life.

While taking calcium supplements, avoid high dosages.

During prophylactic or therapeutic use, regular monitoring of blood and urine tests is recommended for the content of calcium and phosphate ions in them.

Overdose

In case of an overdose of the drug, the following symptoms may develop:

• nausea, dizziness up to;
• sudden weight loss, refusal to eat;
• dry mouth;
• diarrhea, bloating, constipation;
• pain in the muscles, temples, spasms in the joints;
• dysfunction of the renal system;
• a sharp increase in blood pressure;
• mental disorders.

In rare cases, cholestatic jaundice may develop, as well as complications from the organs of vision.

In case of an overdose of the drug and the development of symptoms, you need to call a doctor. While waiting for the brigade to drink more fluids. If hospitalization is required to eliminate the symptoms of an overdose, it is recommended to go to the hospital to avoid serious consequences.

Storage conditions

Drops should be stored in a dark place, out of the reach of children, at a room temperature not higher than 25 degrees, no longer than 3 years from the production date indicated on the package.

Drug analogues

Instead of Akvadetrim, the following medicines can be used:

1. is a complete analogue of the drug Akvadetrim. It is available in the form of an oily solution for oral administration, which can be prescribed to premature and full-term babies older than 2 weeks. Caution should be taken during pregnancy and lactation.
2. Vitamin D3 contains cholecalciferol as an active ingredient. It is produced in the form of drops, which are approved for use in children older than 14 days. The drug can be prescribed, including premature babies. During gestation and lactation, Vitamin D3 should be prescribed with caution, since its chronic overdose in pregnant women can lead to congenital pathologies in the newborn.
3. Aqua D3 is a domestic drug produced in drops, the therapeutic effect of which is explained by colecalciferol. The drug is approved for infants older than 2 weeks of age. The drug in high dosages is not allowed for women who are carrying a baby and supporting natural feeding.
4. Multi-tabs baby is a combination drug that comes in drops. In addition to vitamin D3, it contains ascorbic acid and retinol. The drug is designed specifically for children of the first year of life.

The price of the drug

The cost of the drug is an average of 189 rubles. Prices range from 175 to 207 rubles.

Release form: Liquid dosage forms. Drops for oral administration.

General characteristics. Composition:

Pharmacological properties:

Indications for use: