Non-steroidal drugs for the treatment of joints of a new generation. List of non-steroidal anti-inflammatory drugs for the treatment of joints and their analogues Glucocorticoids for injection into the joint

Non-steroidal anti-inflammatory drugs are included in the international standards for the treatment of inflamed joints and degenerative-dystrophic diseases (spondylosis, osteochondrosis, deforming arthrosis, ankylosing spondylitis).

Non-steroidal anti-inflammatory drugs is proven and clinically effective method treatment. Medicines eliminate inflammation and pain in a relatively short period. The visible effect occurs already 3-5 days after use. Many of the NSAIDs can be bought without a prescription.

Unlike glucocorticoids, non-steroidal anti-inflammatory drugs have fewer side effects. Compared with chondroprotectors, NSAIDs have a faster clinical effect.

What is an NSAID?

Non-steroidal anti-inflammatory drugs are medicines that relieve pain, normalize body temperature and suppress inflammation in the joints. The word "non-steroidal" emphasizes their origin and chemical structure. This is non-hormonal drugs. In this they differ from steroidal anti-inflammatory drugs (glucocorticoids), which provoke many side effects, but have greater anti-inflammatory activity.

Pharmaceutical efficacy

Inflammation is a universal protective process. The task of inflammation is to neutralize the harmful agent. But this process is followed by "side" effects: pain, limitation of movement in the joint, stiffness, swelling, and a decrease in the standard of living.

Regardless of the location of the damage, inflammation always proceeds through the same mechanisms. The task of non-steroidal anti-inflammatory drugs is to neutralize the biochemical chain of inflammation, after which pain will decrease, swelling and stiffness will be eliminated.

Inflammation in the joints develops due to the production of prostaglandins- protein substances that act on pain receptors, increase vascular permeability, create edema, increase local and general body temperature. The soft tissues of the joint become inflamed, the joint increases in volume, hurts and is limited in movement.

Non-steroidal anti-inflammatory drugs block the biochemical chain of conversion of arachidonic acid into prostaglandins in the joints by inhibiting cyclooxygenase (COX) of the first and second types. So NSAIDs relieve joint pain, reduce swelling and block the entire process of inflammation.

What groups of drugs help with pain?

Non-steroidal anti-inflammatory drugs are divided into groups depending on the method of synthesis and chemical structure.

Not all of the active substances presented are used to treat inflammation of the joints. Some of them (paracetamol) have weak anti-inflammatory activity, are used primarily to relieve pain and eliminate fever. This does not cancel their anti-inflammatory effect, they are just weaker.

Non-steroidal active ingredients with the highest anti-inflammatory activity for joints:

Release form: injections, tablets, suppositories, ointments

Anti-inflammatory nonsteroidal drugs for the treatment of joints are available in gels and creams, ointments, tablets, capsules, rectal suppositories and injection solutions.

1. Diclofenac:
2. Ketorolac:
3. :
   • pills: Brufen SR, Deblok, Ibuprofen Velfarm, Nurofast, Nurofen, Solpaflex, Brustan;
   • ointments and gels: Dolgit, Nurofen Express, Deep Relief, Next Activegel;
   • rectal suppositories: Brudol for children, Nurofen for children.
4. Ketoprofen:
5. Indomethacin:
6. Piroxicam:
   • pills: Vero-Piroxicam;
   • gels: Piroxicam, Finalgel.
7. Flurbiprofen:
   • pills: Rakstan-Sanovel;
   • spray for local application: Strepsils Intensive.

The best painkillers of the new generation

Non-steroidal anti-inflammatory drugs for the joints of a new generation cause less side effects , but in terms of anti-inflammatory power, they are the same as the representatives of the previous generation.

Their relative safety is due to the fact that these drugs selectively, that is, selectively inhibit type 2 cyclooxygenase. This distinguishes them from first-generation drugs, which equally block COX-1 and COX-2, cause side effects from the organs of the gastrointestinal tract.

Another advantage of new generation non-steroidal anti-inflammatory drugs for joints is that they do not have an antithrombotic effect and do not affect blood composition.

At nonsteroidal drugs the new generation has a drawback - they increase the likelihood of myocardial infarction, heart failure and hemorrhagic stroke.

When assessing the benefit-risk ratio, selective COX-2 inhibitors for target patients (without a predisposition to cardiovascular diseases) have more benefit than risk.

The new generation includes drugs for the treatment of knees, hip, elbow and other joints with such active ingredients:

Scientists have perfected first-generation non-steroidal anti-inflammatory drugs - they came up with retard tablets(from English slowdown, delay), which reduce the likelihood of side effects. The essence of retard tablets is that the active substance is released more slowly and is processed. It is enough to drink one tablet per day to stably maintain the amount of the active substance in the blood.

Representatives of innovative anti-inflammatory drugs "retard":

1. Diclofenac Retard Obolenskoye, Dicloberl Retard;
2. Metindol Retard, Indomethacin Retard.

What NSAIDs are prescribed for Bechterew's disease, arthrosis and other pathologies?

Anti-inflammatory nonsteroidal drugs for joint diseases are prescribed depending on the individual characteristics of the patient: the rhythm of pain, the degree of stiffness, the presence of stiffness in the morning, secondary diseases and the tolerance of a particular drug. The duration of the use of non-steroidal anti-inflammatory drugs for the joints depends on these same properties.

IMPORTANT! Doses, forms of release, duration of treatment and admission rules are determined by the attending physician. The following information is for informational purposes only.

The disease is treated according to clinical protocols developed by experts from the Ministry of Health:

1. ankylosing spondylitis(protocol 2013): celecoxib, meloxicam;
2. arthrosis(protocol 2016): paracetamol, diclofenac, aceclofenac, etoricoxib, lornoxicam, meloxicam, nimesulide;
3. reactive arthritis(2016 protocol): diclofenac, aceclofenac, nimesulide, meloxicam, etoricoxib;
4. rheumatoid arthritis (protocol 2014): ibuprofen, diclofenac, naproxen, celecoxib, etoricoxib;
5. pseudoarthrosis(protocol 2014): ketoprofen, ketorolac, paracetamol;
6. psoriatic arthritis(protocol 2016): diclofenac, aceclofenac, etoricoxib, meloxicam;
7. deforming osteoarthritis(protocol 2016): diclofenac, aceclofenac, etoricoxib, lornoxicam, meloxicam.

General contraindications

Anti-inflammatory non-steroidal drugs for the joints should not be taken if the patient has:

Take only under the supervision of a physician for the following disorders:

• arterial hypertension;
• diabetes;
• mental disorders;
• age over 60 years.

How long can the medicines be used?

To make your reception as safe as possible, adhere to the following information:

1. injections - no longer than 3 days;
2. rectal suppositories - no longer than 2 days;
3. tablets and capsules - 10-14 days;
4. ointment, gel and cream - no longer than 14 days;
5. spray for external use - no longer than 3 days.

Useful video

The program "Live Healthy" tells about the rules for taking non-steroidal anti-inflammatory drugs.

Results:

1. Non-steroidal anti-inflammatory drugs are included in the international clinical guidelines for the treatment of joint diseases.
2. NSAIDs relieve pain, suppress inflammation and increase joint mobility.
3. Substances with the greatest anti-inflammatory activity: diclofenac, ketorolac, ketoprofen, ibuprofen, indomethacin, piroxicam, meloxicam, nimesulide, flurbiprofen.
4. For the treatment of joints, non-steroidal anti-inflammatory drugs are available in the form of tablets and capsules, injection solutions, rectal suppositories, ointments, gels and sprays for external use.
5. New generation NSAIDs are safer but not recommended for patients with cardiovascular disease. The new generation non-steroidal anti-inflammatory drugs include such substances: meloxicam, celecoxib, nimesulide and etoricoxib.
6. NSAIDs should not be taken by patients with acute gastrointestinal disease, hemophilia and severe conditions.
7. The maximum duration of injections is 3 days, rectal suppositories - 2 days, tablets and capsules - 10-14 days, ointments, gels and creams - 14 days, sprays - 3 days.

Every third person over the age of 35 experiences joint pain. They are aching and sharp, point and widespread, short-term and long-term. Whatever the pain, they affect the quality of life, often leading to disability. The reasons for their occurrence are different. Pain sensations appear in endocrine, infectious, rheumatic, tumor and other diseases. For their diagnosis and further treatment, it is necessary to undergo a complete medical examination. To reduce pain, and sometimes get rid of it, special means will help: ointments, creams, gels and various oral preparations. They are aimed not only at relieving the syndrome, but also perform an anti-inflammatory function.

By choosing the right remedy for the joints, you can significantly reduce pain quickly relieve inflammation and swelling. We have ranked the best drugs for joints, considering the following factors:

• patient reviews;
• opinion of doctors;
• efficacy after application.

There are contraindications. Check with your doctor.

The best ointments, creams and gels for joints

Pain may come on unexpectedly. Special ointments, creams and gels will help to quickly get rid of it, which will reduce discomfort. Many of them not only stop the pain syndrome, but also have an anti-inflammatory effect. The use of the drug increases blood flow, restores joint mobility. Ointments are made on the basis of natural ingredients: bee or snake venom, hot pepper, eucalyptus or clove oil.

5 FASTUM GEL

gentle impact
Country: Germany
Average price: FASTUM GEL
Rating (2019): 4.7

The active substance of "Fastum Gel" is ketoprofen, which belongs to non-steroidal anti-inflammatory drugs. The drug not only relieves pain and swelling, but also affects the cause of their occurrence. It is used to treat joints, muscles, tendons and ligaments in rheumatism, arthritis, gout, osteochondrosis, sports injuries. After using the medicine, the blood supply increases, as a result, mobility returns, pain, inflammation and fever disappear.

The gel with a pleasant smell and delicate texture is instantly absorbed into the skin and begins to act within a few minutes. The pain will soon disappear completely. The effect lasts from 2 to 4 hours. The advantages include a quick and gentle effect, the drug is not addictive, neutral aroma, economical consumption. No cons found.

4 VOLTAREN EMULGEL

Most popular remedy
Country: Switzerland
Average price: 280 rubles.
Rating (2019): 4.7

The Swiss drug of complex action "Voltaren Emulgel" quickly eliminates pain in muscles, ligaments and joints. Thanks to diclofenac, which is part of it, it has a pronounced anti-inflammatory, analgesic and antipyretic effect. It relieves puffiness and restores mobility, improves metabolic processes. Diclofenac is recognized as the most effective non-steroidal agent. According to reviews, gels based on it are the best medicines to reduce pain and relieve tension from muscles and joints.

The product with a pleasant texture is quickly absorbed, does not leave marks on the skin, and smells pleasant. The effect occurs in a few minutes, soon the discomfort and swelling subside. Advantages: powerful analgesic effect. Disadvantages: Side effects may occur.

3 LONG

The best combination of price and quality
Country: Germany
Average price: 130 rubles.
Rating (2019): 4.8

A powerful anti-inflammatory agent quickly and effectively relieves pain and swelling, restores muscle mobility. It is indicated for arthritis, rheumatism, gout, osteochondrosis, sciatica. The cream is suitable for sprains, sprains, bruises and other injuries, and also has a warming effect before training. The active ingredient ibuprofen, which belongs to non-steroidal anti-inflammatory drugs, has a strong analgesic effect. The cream relieves heat, redness, promotes resorption of hematomas.

After application, a warming effect is felt for several minutes, the pain syndrome gradually disappears. A stable result appears after 15 minutes and lasts up to 6 hours. Advantages: wide spectrum of action, effectively relieves pain and swelling, optimal cost. Cons: with individual intolerance to the drug, allergic reactions are possible.

2 Kapsikam

natural remedy
The country:
Average price: 260 rubles.
Rating (2019): 4.9

Kapsikam is an ointment of combined action. It has an irritating, vasodilating and analgesic effect. The drug is made on the basis of hot pepper extract. It is great for joint pain, often used by athletes to warm up muscles before training. The ointment is quickly absorbed, after a few minutes it causes a feeling of warmth. The temperature of the skin rises, thereby increasing blood flow to the treated area. Muscle spasms stop.

The positive effect occurs after 30 minutes, which lasts up to 6 hours. Advantages: fast-acting pain reliever, natural ingredients in the composition, few contraindications, optimal price. Disadvantages: on sensitive skin, a strong burning sensation is felt.

1 Viprosal

Better Efficiency
The country: Latvia (produced in Estonia)
Average price: 230 rubles.
Rating (2019): 5.0

The ointment is based on viper venom, which has an irritating effect and promotes vasodilation and blood flow. The composition also includes salicylic acid, turpentine and camphor, which are excellent antiseptics. The drug is recognized as the best fast-acting pain reliever. It is used for sprains and bruises, shown to athletes with severe physical activity.

The drug is quickly absorbed, so relief comes in a few minutes, and the pain syndrome completely disappears after 30. The effect lasts 2-3 hours. The product is available in tubes, economically consumed, one package is enough for a long period of use. Advantages: ointment based on natural ingredients, instant action, few side effects, optimal cost. No cons found.

The best pills for joints

Joint pain is the cause various diseases. These are arthritis, arthrosis, gout and others. It can appear as a result of injuries in athletes or after strong physical exertion. To eliminate unpleasant symptoms, it is necessary to identify their cause. Tablets and vitamins for joints have a preventive, anti-inflammatory, antipyretic, analgesic and anti-edematous effect. These are the most common types of drugs recommended by doctors and used by patients.

5 Texamen

Long-term use allowed
Country: Turkey
Average price: 174 rubles.
Rating (2019): 4.6

Taking the drug relieves pain, relieves inflammation, knocks down high temperature, eliminates swelling of the joint and prevents the formation of blood clots. Refers to oxicam derivatives. Recommended for the treatment of bursitis, gout, different kind neuralgia, osteoarthritis, rheumatism, myalgia. Eliminates pain of a traumatic nature, when there is no result from ointments, creams or gel. Quickly brings the joint into working condition. Long-term use of the drug is safe for the body. Patients with progressive diseases of the urinary system are treated with caution and under the supervision of a doctor.

Texamen quickly and deeply enters the joint 2 hours after its use. Absorption takes place in the digestive tract. A single dose per day is sufficient. It is recommended to take painkillers at the same time each day for maximum results. Dose for a single dose - no more than 20 mg. If the drug is used for more than 5 days, then the volume of one dose is halved. For an effective effect on the patient, doctors advise drinking the smallest dose in a short course. The upcoming operation serves as a reason for discontinuation of the drug. An attack of gout is allowed to be removed with an increased dosage - 40 mg. After removal acute syndrome switch to a five-day course.

4 Ketorolac

Best price. Effective for intense pain
Country Russia
Average price: 35 rubles.
Rating (2019): 4.7

It is used to treat patients with severe pain syndrome. It is considered one of the fastest acting tools. The main component of the drug is trometamol. It reduces the activity of lipid compounds, relieving the patient of pain of varying intensity. The drug is available in several forms: tablets, in the form of a gel, drops, liquid. It has antipyretic, anti-inflammatory properties. It is not addictive and does not have a narcotic, sedative effect. Ketorolac is not recommended for chronic pain syndrome.

The action of the drug begins 40-60 minutes after administration. The highest concentration is observed after 3 hours. Tablets are completely absorbed in the intestine. The use of fatty foods can increase the time of action of the drug. Recommended for single or double use. The first dose - 10 mg, the second - up to 4 times a day, 10 mg. The maximum period of admission is 5 days.

3 LORNOXICAM

Rapid pain relief
Country: Austria
Average price: 150 rubles.
Rating (2019): 4.8

Lornoxicam is one of the strongest painkillers in its group. It relieves unpleasant symptoms in arthritis (rheumatoid and infectious), gout, arthrosis. Reduces stiffness and swelling of the joints. Instantly relieves pain, slows down the inflammatory process, relieves fever. The effect remains up to 8 hours. The drug is rapidly and completely absorbed.

Lornoxicam is included in the list of vital and essential medicines. It is available in the form of hard film coated tablets. Patient reviews indicate the effectiveness of the drug with severe and moderate pain. Before use, you should consult with your doctor. Benefits: Rapid pain relief, reduced inflammation. Disadvantages: there are contraindications.

2 MOVALIS

Effective anti-inflammatory action
Country: Austria
Average price: 520 rubles.
Rating (2019): 4.9

The drug is intended for the treatment of arthrosis, arthritis and other diseases of the musculoskeletal system. It belongs to non-steroidal anti-inflammatory drugs. It has analgesic and antipyretic effect. After using the tablets, swelling decreases and stiffness in movements is eliminated. As a result of laboratory studies, it was proved that movalis affects inflammation of various etiologies.

A high therapeutic effect is achieved with complex treatment. The agent is well absorbed from the gastrointestinal tract. Advantages: rapid reduction of inflammation, prevention of diseases of the musculoskeletal system, combined with other drugs, few side effects. No cons found.

1 TERAFLEX

Better cartilage repair
Country: Germany
Average price: 1,300 rubles.
Rating (2019): 5.0

The drug contains natural ingredients glucosamine and chondroitin. They restore cartilage tissue, increase collagen synthesis, relieve inflammation and pain, and improve mobility. It is indicated for use in osteochondrosis, osteoarthritis, osteoporosis, pathology of the spine and joints. Tablets stimulate tissue regeneration and prevent cartilage destruction.

The therapeutic effect is achieved with long-term and regular treatment. The remedy is recommended to be taken 2 times a year in spring and autumn for 3 months. Benefits: an effective stimulator of cartilage tissue regeneration, relieves inflammation and pain, is well tolerated by patients. The downside is the duration of the drug and the high price.

The best vitamins for joints

For help to sick joints, they often turn to vitamin-mineral complexes. They play an important role in complex therapy sick. The most effective of them are presented below.

5 ARTRIVIT

Based on herbal ingredients
Country: Canada
Average price: 330 rubles.
Rating (2019): 4.6

Vitamin-mineral preparation "ArtriVit" is intended for complex treatment musculoskeletal system and joints. It is recommended to use for athletes with increased physical exertion, as well as during the recovery period after injuries. The tool has a preventive effect in osteoporosis. It provides the joints with essential nutrients and stimulates tissue metabolism.

After application, pain and swelling decrease, flexibility improves, the crunch disappears. In addition to vitamins and minerals, the composition includes plant extracts: skullcap roots, licorice and black cohosh, alfalfa. Natural ingredients have anti-rheumatic, anti-inflammatory and antibacterial effects, normalize the temperature. Advantages: effective remedy, there are no contraindications (except for individual intolerance). No cons were found.

4 CALCEMIN

High quality preventative
Country Russia
Average price: 370 rubles.
Rating (2019): 4.7

The strength of bone tissue directly depends on the amount of calcium in the body. The natural mineral complex "Kalcemin" makes up for its deficiency. The composition contains zinc, manganese, copper, boron, vitamin E3, which contribute to the restoration of cartilage, reduce inflammation, and increase the absorption of trace elements. The drug is recommended for the complex treatment and prevention of osteoporosis.

According to reviews, this excellent tool to strengthen bones and joints. Suitable for children over 5 years old, as well as pregnant and lactating women. The average duration of the prophylactic course is 30 days, for the treatment of osteoporosis - 3 months. Advantages: natural composition, easy to digest, few side effects, optimal price. No deficiencies found.

3 Artron Complex

Helps normalize the formation of joint fluid
Country: USA
Average price: 550 rubles.
Rating (2019): 4.7

The best modern drug from the group of chondroprotectors. Contains chondroitin and glucosamine. Additionally included are magnesium stearate, MCC, calcium phosphate. Glucosamine produces collagen, which is actively involved in the formation of the structure of the joint. It has an anti-inflammatory effect, acts as an antioxidant. The patient acquires lost physical activity. Chondroitin is considered to lubricate the joint, providing it with youth and mobility. The drug stimulates regeneration, normalizes blood circulation, provides nutrition to bone tissue. Thanks to this, pain disappears, saturation with minerals occurs, and injured areas are restored.

Artron Complex is indicated for use by athletes, hard physical workers, the elderly in the recovery period after fractures. Starting from the age of 15, it is recommended to drink the medicine 1-3 times a day, 1 tablet. Improving the patient's condition is the reason for reducing the dosage to one tablet per day. An effective course of therapy reaches 3 months. Treatment is enough to carry out 2 times a year.

2 Doppelhertz asset

Serves as a building block for cartilage
Country: Germany
Average price: 528 rubles.
Rating (2019): 4.8

The drug is considered the best biologically active food supplement. It is prescribed for the preventive purpose of dystrophic processes in the joints and spine. active ingredients are glucosamine and chondroitin. They are involved in the construction of connective, cartilage tissues. Helps restore bone tissue after injury. The composition of the product includes Ca, which provides better strength of the joints and bones, and also improves the functioning of all systems and organs, increases the amount of hemoglobin in the blood.

Doctors recommend taking the drug from adolescence, when there is an active growth of the musculoskeletal system. Vitamins are prescribed to people who experience a large mechanical load on the joints during work. Tablets are taken during the day and in the evening, thoroughly washed down with water. The effective time of administration is after eating. The duration of treatment is discussed with the doctor. Usually take the drug for up to three months. Then they take a break, and it is possible to repeat the course.

1 Calciferol

Best way to prevent and treat osteoporosis
Country: USA
Average price: 1,160 rubles.
Rating (2019): 5.0

The basis of the drug is vitamin D, the main function of which is considered to be the normalization of Ca absorption in the body. Due to this, it inhibits osteoporosis, serves as a preventive measure against osteomalacia in people of all ages. Doctors prescribe vitamin to children from the first days of life, as the safest in the fight against rickets. In order to prevent fractures, the drug is prescribed to elderly patients, whose bone tissue becomes thinner with age. Must be taken by pregnant women. This will help to properly form the baby's skeleton and preserve the mother's bone structure.

The drug is taken orally. The best dosage is selected individually by the doctor, taking into account age, physical activity, and the starting content of the vitamin in the patient's body. 400-600 IU are prescribed per day. For effective prevention, the use of 200 IU per day is acceptable. Adolescents from 8 to 12 years old are prescribed 1 tablet per day, adults - 2 times a day, without chewing. Regular vitamin intake improves performance nervous system, normalizes sleep.

The best drugs for intra-articular administration

At the beginning of the onset of the pain syndrome, patients begin to actively use external agents in the form of an ointment, cream or gel for treatment. With the disappearance of unpleasant symptoms, treatment is stopped, but inflammatory processes sometimes proceed deeper than these agents penetrate. Then intra-articular injections are required. The method is considered innovative and most effective in the fight against arthritis, arthrosis. It is carried out only in a hospital by a specially trained medical professional. As a result of intra-articular infusion, pain is relieved, swelling decreases and inflammation is eliminated.

5 Kenalog

Limits the movement of leukocytes to the area of ​​inflammation
Country: Slovenia
Average price: 570 rubles.
Rating (2019): 4.6

The action of the drug is based on the inhibition of neurotransmitters by eosinophils, which suppresses the development of inflammation. The introduction into the joint is recommended for bursitis, arthritis of traumatic etiology, tendonitis and synovitis. With deep penetration of the agent, the movement of leukocytes to the lesion is inhibited. It is recommended to use the remedy for the treatment of minor residual foci of inflammation, gout, dropsy. It successfully treats the wrinkling of the bag of the shoulder joint.

The standard dosage for people over 12 years of age depends on the parameters of the joint and the nature of the course of the disease. For introduction into small joints, 10 mg is enough, medium - 20 mg, large - up to 40 mg. Detection of an extensive area of ​​inflammation or a large number of joints, the dose per day is increased to 80 mg. Preparation of the injection site is similar to preoperative. The interval between injections is at least 2 weeks. The duration of therapy depends entirely on the body's response to treatment, which is evaluated by the doctor.

4 Hydrocortisone

Has an anti-shock effect
Country Ukraine
Average price: 214 rubles.
Rating (2019): 4.7

A hormonal drug classified as a potent drug. It is actively used for severe inflammation, autoimmune diseases, shock conditions. Inside the joint is introduced in a medical institution, under the strict supervision of a doctor. The procedure is equivalent to a surgical intervention, requires careful preparatory measures and complete disinfection. They try to use the drug in the most difficult cases, when there is a high risk of a threat to the patient's life or in the absence of the desired result of preliminary treatment. The action is based on a process that suppresses the patient's immunity. The body accelerates the breakdown of proteins in the muscles.

As a result of exposure, puffiness is removed, the total volume of blood in the body increases, blood pressure. When injected into the joint, there is a slow breakdown of the components of the drug, which stretches the period of its action. A single dose of the drug depends on the size of the joint and its damage and varies from 0.1 to 1.0 ml. Injections are made 1 time in 7 days. The full course is 3-5 procedures. The analgesic effect begins after 6-24 hours from the moment of administration. The effect of the drug is observed for up to several weeks. Additionally, it is available in the form of an ointment, gel and cream based on it.

3 Diprospan

Strong anti-inflammatory agent
Country: USA
Average price: 383 rubles.
Rating (2019): 4.8

The drug has glucocorticosteroid activity. It is prescribed as a strong anti-inflammatory agent, when ointments and creams have not previously helped. It has antihistamine and immunosuppressive effects. Concentrated in the liver and excreted by the body through the urinary system. Produced in the form of a suspension intended for intramuscular, intraarticular, intradermal injections. Used for skin diseases, musculoskeletal disorders, nephrotic syndrome, allergies. The drug can play the role of adjuvant therapy against the background of the main treatment. The crystals of the drug are small in size, which allows the use of the smallest needles for injections. The process of introduction into the focus of inflammation becomes less painful. Such procedures should be carried out in conditions of increased disinfection.

The dosage is chosen only by the doctor, depending on the age of the patient, the severity of the symptoms and his general condition. A single volume is 1-2 ml, the frequency of administration is individual. For effective exposure, the use of the minimum allowable doses for a short period of time is indicated. Cancellation of the drug occurs according to the scheme prescribed by the doctor.

2 Flosteron

Has an antitoxic effect
Country: Slovenia
Average price: 1,107 rubles.
Rating (2019): 4.9

Produced in the form of a suspension. It is used in anti-shock measures, reduces the toxic effect and vascular permeability circulatory system. Due to this, after the introduction, it quickly penetrates to the focus of inflammation, easily overcoming even the placental barrier. It breaks down in the liver into inactive metabolites. Excretion routes: kidneys, bile and breast milk.

The dosage of the drug depends on the size of the joint and the degree of its damage. When developing a treatment regimen, the doctor focuses on the patient's age, severity of the disease and individual characteristics. For large joints, this figure is 1-2 ml, medium - 0.5-1 ml, and for small joints - from 0.25 to 0.5 ml. Exceeding the dose is possible with confirmed symptoms of gout. The frequency of administration of the drug for large joints is 3-4 times a year. Single doses should not be exceeded. Re-introduction of funds is allowed after 7-14 days. It is acceptable to mix the drug with a local anesthetic.

1 Don

Better cartilage regeneration
Country: Italy
Average price: 1,330 rubles.
Rating (2019): 5.0

The drug behaves as an active chondroprotector, a strong analgesic and anabolic agent. It has a pronounced anti-inflammatory effect, starts the process of regeneration of injured tissues and affects the absorption nutrients. The pain goes away, the inflammation is eliminated, the patient's physical activity is restored. The basis of the drug is glucosamine, which activates the regenerative process in cartilage tissue. The permeability of the articular membrane increases, which leads to the normalization of all processes.

The dose of administration and the treatment regimen is developed by the doctor individually for each patient. A solvent is used to dilute the suspension. It is mixed with the main drug and administered simultaneously. It is tolerated without complications, but in patients with diabetes it is necessary during treatment to control the level of glucose in the body.

Content

Pain in the joints is excruciating and unbearable, it prevents a person from living normally. Many people have firsthand experience of how difficult it is to tolerate this phenomenon. If this problem has also affected you, then non-steroidal anti-inflammatory drugs for the treatment of joints will come to the rescue. You will soon find out which of them are really capable of relieving pain.

What are non-steroidal anti-inflammatory drugs

These drugs are abbreviated as NSAIDs. Starts with them drug treatment arthrosis. Anti-inflammatory drugs are called nonsteroidal because they do not contain hormones. They are safer for the body and give a minimum of side effects. There are selective agents that act directly on the focus of inflammation, and non-selective agents that also affect the organs of the gastrointestinal tract. The first one is preferable.

Treatment of joints NSAIDs

Means must be prescribed by a doctor, based on the intensity of pain and the manifestation of other symptoms. Diagnoses in which NSAIDs help:

• infectious, aseptic, autoimmune, gouty or rheumatoid arthritis;
• arthrosis, osteoarthritis, deforming osteoarthritis;
• osteochondrosis;
• rheumatic arthropathy: psoriasis, ankylosing spondylitis, Reiter's syndrome;
• bone tumors, metastases;
• pain after surgery, trauma.

Anti-inflammatory drugs for joints

The range includes pharmacological agents in the form of:

• tablets;
• intramuscular injections;
• injections into the joint itself;
• plasters;
• candles;
• creams, ointments.

In severe forms of joint diseases and a deterioration in the patient's well-being, the doctor, as a rule, prescribes stronger medicines. They help quickly. We are talking about injections in the joint. Such drugs do not spoil the gastrointestinal tract. In milder forms of the disease, the specialist prescribes pills, intramuscular injections. The use of creams and ointments is always recommended as an addition to the main therapy complex.

Pills

There are such effective NVPS (means):

1. "Indomethacin" (another name is "Metindol"). Pills for joint pain relieve inflammation, have an antipyretic effect. The drug is drunk twice or thrice a day for 0.25-0.5 g.
2. "Etodolak" ("Etol Fort"). Produced in capsules. Anesthetizes quickly. Acts on inflammation. It should be taken one tablet 1-3 times after meals.
3. "Aceclofenac" ("Aertal", "Diclotol", "Zerodol"). diclofenac analogue. The drug is taken on a tablet twice a day. The drug often causes side effects: nausea, dizziness.
4. "Piroxicam" ("Fedin-20"). They have an antiplatelet effect, relieve pain, fever. The dosage and rules of admission are always determined by the doctor, based on the severity of the disease.
5. Meloxicam. Tablets are prescribed one or two per day after the disease passes from the acute stage to the next.

Ointments for the treatment of joints

Classification:

1. With ibuprofen ("Dolgit", "Nurofen"). An anti-inflammatory and analgesic ointment for joints with such a main component will help those with arthritis, trauma. Acts very quickly.
2. With diclofenac ("Voltaren", "Diklak", "Diclofenac", "Diklovit"). Such medicinal ointments warm up, relieve pain and block inflammatory processes. Quickly help those who have difficulty moving.
3. With ketoprofen ("Ketonal", "Fastum", "Ketoprofen Vramed"). Prevent the formation of blood clots. With too long use of ointments, a rash may appear on the body.
4. With indomethacin ("Indomethacin Sopharma", "Indovazin"). They act similarly to drugs based on ketoprofen, but less intensively. They warm well, help with rheumatoid arthritis, gout.
5. With piroxicam ("Finalgel"). They relieve painful symptoms, do not dry the skin.

injections

There are such NSAIDs for injection:

1. "Diclofenac". Relieves inflammation, pain, is prescribed for severe diseases. Intramuscularly injected 0.75 g of the drug once or twice a day.
2. "Tenoxicam" ("Teksamen L"). Soluble powder for injection. 2 ml per day is prescribed for mild pain syndrome. The dose is doubled and a five-day course is prescribed for gouty arthritis.
3. "Lornoxicam" ("Larfix", "Lorakam"). 8 mg of the drug is injected into a muscle or vein once or twice a day.

Anti-inflammatory non-steroidal drugs of a new generation

More modern, and therefore more effective means:

1. "Movalis" ("Mirloks", "Artrozan"). Highly effective drug, produced in tablets, injection solution, suppositories. Virtually no side effects. For injections use 1-2 ml of solution per day. Tablets are taken at 7.5 mg once or twice a day.
2. "Celecoxib". Does not have a detrimental effect on the stomach. Take one or two tablets per day, but not more than 0.4 g of the drug per day.
3. Arcoxia. The drug is in tablets. The dosage is prescribed depending on the severity of the disease.
4. "Nimesulide". Available in tablets, sachets for dilution, in the form of a gel. The dose is determined by the doctor, as well as the rules of admission.

Diseases of the musculoskeletal system, ligaments and joints are in the ranking of the most popular diseases after diseases of the cardiovascular system and neurological abnormalities. The age threshold of patients has also been reduced: an increasing number of people under the age of forty turn to orthopedists with complaints about and ligaments. After contacting a doctor and determining the diagnosis, treatment is prescribed, including non-steroidal anti-inflammatory drugs.

General information

Non-steroidal anti-inflammatory drugs - such a pharmaceutical group of drugs that is used in the treatment and prevention of inflammation:

1. Large and small joints.
2. Ligaments.

The main action of NSAIDs is aimed at removing:

• pain;
• inflammation;
• heat.

The development of this group of drugs was preceded by the discovery of salicylic acid, obtained from the bark of the willow in 1829. Since then, nonsteroidal drugs have been an indispensable group of drugs. The meaning of the treatment of joints and ligaments with non-steroidal anti-inflammatory drugs is based on the suppression of the production of prostaglandins due to cyclooxygenase.

By chemical structure nonsteroidal drugs divided into 2 large groups:

1. Acidic - the most common group containing at its core acid (salicylic acid), the directed action of which effectively relieves fever and anesthetizes. These drugs include Ibuprofen, Meloxicam.
2. Non-acid - anti-inflammatory drugs that direct their action to suppress inflammation and pain. These drugs include Ketoprofen and them.

Dr. Epifanov explains the mechanism of action:

Side effects and contraindications

In medicine, there are no other ways to treat joints and ligaments, except for the appointment of non-steroidal anti-inflammatory drugs. NSAIDs, despite their powerful effect in relieving inflammation, have a long list of side effects. The most common are:

• indigestion;
• nausea and vomiting;
• loss of vision and hearing;
• dry mouth;
• heart palpitations;
• violation of hematopoiesis;
• allergies;
• blurred vision and tinnitus;
• pain in various organs;
• drowsiness.

Due to serious side effects non-steroidal drugs are contraindicated in persons with:

1. Ulcerative colitis.
2. Gastritis, erosion, stomach ulcers.
3. Children's age up to 12 years.
4. Pregnancy, lactation period.
5. Hypersensitivity to the components of the drug.
6. Liver or kidney failure.

Non-steroidal anti-inflammatory drugs come in various forms. There are certain advantages of one form over another. Sometimes the appointment of a specific form for the treatment of joints and ligaments is fundamentally important. Non-steroidal anti-inflammatory drugs for the treatment of joints have the following forms of release:

1. (gels, creams).
2. Plasters.
3. Suppositories.
4. Suspensions.
5. Capsules.

Advantages and disadvantages

Each release form has its own advantages and disadvantages. Depending on the type of disease, its severity, time of course and form, the type of drug, its specific form, is prescribed. Sometimes several forms can be prescribed for treatment at once. For example, injections (shots) and tablets at the same time or tablets, ointments and gels.

Injections (shots) are prescribed by a doctor for the treatment of joints and ligaments, if the disease is in an acute stage, and inflammation, pain must be removed quickly in order to alleviate the patient's suffering and prevent the disease from hitting new foci. Injections can be administered intravenously or intramuscularly (more often), a course of 7 to 10 days twice a day. Injections are the first in the list in terms of the frequency of prescription for patients with pain in the joints and ligaments.

Advantages of injections:

• speed of action;
• minimal risk of damage to the gastric mucosa;
• no time is required for the absorption of the drug into the walls of the stomach.

Disadvantages of injections:

1. Painful insertion.
2. Inconvenience (it is impossible to self-administer the drug).

Ibuprofen is an acid derivative drug with antipyretic, analgesic effect. This is one of the few drugs that is allowed:

1. Children over 3 months old.
2. Pregnant women.
3. Nursing mothers.

Release forms:

• suspension;
• pills;
• ointments;
• gels.

Indomethacin, a drug widely used to relieve inflammation and pain, belongs to the group of non-acid derivatives. Its release form:

1. Pills.
2. Ointment.
3. Candles.
4. Gel.
5. Capsules.

Painkillers of the indomethacin group are also prescribed for adults and children.

Nimesulide is a relatively recently developed drug prescribed for the treatment of degenerative processes in joints and tissues. The advantages of nimesulide are in a small list of contraindications. Available in the form:

• tablets;
• injections;
• ointments;
• candles.

Ketoprofen is one of the most powerful anti-inflammatory nonsteroidal drugs with analgesic effects. Widely applicable by orthopedists for the treatment of diseases:

1. joints.
2. Backs.
3. Ligaments.

Release forms:

• pills;
• injections;
• gels.

Conclusion

Medicines prescribed for the treatment of pathologies of the musculoskeletal system, in particular, joints and ligaments, have analgesic, antipyretic, anti-inflammatory effects.

Non-steroidal drugs are mandatory in the treatment of diseases of the musculoskeletal system. Each pharmacological form of release (tablets, injections, gels, ointments, creams, suppositories, patches, suspensions) has its own advantages and disadvantages. The choice of a specific form depends on the patient's age, type of disease, general health.

They direct their action to suppress the production of prostaglandins that affect the occurrence of inflammation.

Diseases of the joints and ligaments are a frequent occurrence that causes a large number of troubles. The disease requires an immediate visit to the doctor for a full treatment, after which you will have to change your lifestyle completely in order to avoid a relapse of the disease.

Joint pain significantly complicates life and interferes with a full life. Pain does not go away on its own. Therefore, treatment is accompanied, first of all, by anti-inflammatory drugs. Their list is quite wide. In structure, they differ from others in the absence of steroid hormones, which allows a large group of patients to take the medicine.

Non-steroidal anti-inflammatory drugs are used to treat large and small joints, as well as ligaments. The disease is accompanied by swelling, pain and hyperthermia. At the same time, prostaglandins are formed in the body - substances that activate the production of hormones in the blood. As a result of the influence on the vessels, the body temperature rises, and inflammatory reactions intensify, which leads to arthritis, osteochondrosis and other unpleasant diseases.

The enzyme cyclooxygenase (COX) is blocked by the non-hormonal action of NSAIDs. Swelling and redness decrease, the temperature returns to normal, inflammation subsides.

NSAIDs have a positive effect on diseases:

• relieve inflammation;
• have analgesic properties;
• effectively lower the temperature;
• have an antiaggregatory effect - eliminate the adhesion of platelets.

Do not forget that drugs - immunosuppressants, help in the treatment of rheumatism, but have a depressing effect on immune system generally.

Classification of drugs

It is worth noting that COX is divided into two types. The first produces prostaglandin, which protects the lining of the stomach and intestines from damage. And the second connects prostaglandins that increase the temperature.

Therefore, drugs are usually differentiated into two parts:

• selective (they inhibit COX2);
• non-selective.

The latter, in turn, are also grouped. Some act equally on both COX, others on COX1.

The former are prescribed for acute respiratory viral infections, after operations, for injuries, infections, others save from rheumatism and diseased joints, have anti-inflammatory properties.

Indications for the use of NSAIDs for the treatment of joints

Anti-inflammatory drugs are safe for short-term use and in the absence of contraindications.

Medicines are used in chronic and acute inflammatory processes:

• migraine;
• trauma;
• arthritis, rheumatism, ankylosing spondylitis;
• toothache;
• gout;
• renal and hepatic colic;
• inflammatory diseases of the spine, muscles, musculoskeletal system, joints and bones;
• sciatica, sciatica, neuralgia;
• painful critical days;
• infections;
• metastases in cancer.

List of non-steroidal anti-inflammatory drugs

Acetylsalicylic acid (aspirin).

In practice for over a hundred years. Assign to fight SARS, relieve headaches. Together with other substances, they are used for the treatment of osteoarthritis. But at acute inflammation aspirin is replaced by more powerful medicines.

Diclofenac.

Available in tablets, suppositories, gel and injection. The popular pain reliever is absorbed within twenty minutes and understands the fever.

Ibuprofen.

Release form - candles, tablets. It is easy to carry, has a low price tag. It is prescribed for neuralgia, bursitis, hematomas, sprains, influenza, SARS, rheumatoid arthritis, gout, Bechterew's disease, osteoarthritis, feverish conditions. Ibuprofen has many analogues in different price categories.

Nimesulide.

When using it, the temperature normalizes, the body becomes mobile as a result of anesthesia. The ointment is applied to the arthritic area. There is a slight redness, so the effect of the drug is manifested.

Indometacin is one of the strongest drugs with analgesic effect.

Produced in the form of ointments, suppositories, tablets. Although the medicine is cheap, this does not prevent it from having an incomparable effect on arthritic and arthrotic joints. Before use, a doctor's consultation is required due to the impressive list of side effects.

Meloxicam belongs to the group of NSAIDs.

Available in tablets and in solution for intramuscular injection. pharmachologic effect- analgesic anti-inflammatory with antipyretic effect. Indicated for symptomatic therapy, reducing pain and inflammation. Treats osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. It is allowed to use meloxicam under the supervision of a specialist even for several years. Long-term exposure allows you to take one tablet during the day. It is possible to purchase a substance under various names - Movalis, Melbek, Melox, Artrozan, Mesipol, Mataren, etc.

Some drugs, under the strict supervision of a doctor, are allowed to be taken by pregnant women in case of vital necessity, in no case in the third trimester.

The doctor may prescribe:

• diclofenac;
• ibuprofen;
• aspirin;
• ketorolac;
• indomethacin;
• naproxen.

It is forbidden to drink medicines on your own.

NSAIDs of a new generation for the treatment of joints

Medical technology does not stand still. Every day, hundreds of scientists are trying to develop the latest pills and modernize the time-tested. Non-steroidal anti-inflammatory drugs have not been spared either. New generation drugs act more selectively and thoroughly suppress inflammation. The most important thing here is the absence of a serious effect on the gastrointestinal tract and cartilage tissue.

List of new generation non-steroidal anti-inflammatory drugs

Among the useful "drugs", Movalis with active substance in the form of meloxicam. With arthrosis, a real lifesaver. Long-term use has practically no effect on the work of the stomach and intestines. Analogues work in the same area - Melbek, Mesipol, Mirloks.

The drug Ksefokam has the ability to stretch the effect of the panacea, so that patients do not feel pain for about twelve hours. Most importantly, Ksefokam is not addictive, and the ability to relieve pain is comparable to morphine. However, the high cost does not allow everyone to purchase the drug in the first-aid kit. Produced by prescription.

The antioxidant Nimesulide blocks the action of substances that break down collagens and cartilage. Arthrosis of the joints is treatable, the pain becomes dull, the inflammation disappears. Sold in granules for solution, tablets, in the form of a gel.

Celecoxib was originally called Celebrex. Release form - capsules 200 and 100 mg. A pronounced fight against arthrosis arthritis does not affect the functioning of the gastrointestinal tract, the mucous membrane remains normal.

Etoricoxib is sold under the brand name Arcoxia. Reception up to 150 mg per day does not affect the functioning of the intestines and stomach. The average dose for arthrosis is approximately 30-60 mg per day.

The cost of medicines varies. On the advice of a doctor, the patient can buy a more expensive drug or its analogue, in accordance with contraindications and side effects. Means stop unbearable pain and eliminate inflammation. After taking them, another treatment should be prescribed.

General application rules

Take on an independent guide to medicines is not worth it. Contacting a specialist will help you understand the methods and rules of treatment. To do this, you need to prepare all statements about previous or concomitant diseases and take tests so that the doctor chooses the right treatment.

Tablets are taken immediately after meals with half a glass of water or low-fat milk to assimilate and protect the gastrointestinal tract from harmful effects. In parallel, bifidobacteria should be taken.

If long-term use is planned, then start with a minimum dose, gradually increasing the amount.

Side effects of non-steroidal anti-inflammatory drugs

1. Allergy.
2. Bronchospasms.
3. Dyspeptic disorders.
4. Violation of renal functions (nephropathy, vessels narrow).
5. Ulcerogenic action (development of erosion or stomach ulcers).
6. Increased blood activity in the liver.
7. miscarriages.
8. In rare cases, bleeding disorders.

Contraindications to the use of NSAIDs

Any, even the most harmless drug, has contraindications. NSAIDs have several of them:

• pregnancy;
• individual intolerance;
• disorders in the work of the kidneys and liver;
• peptic ulcers of the gastrointestinal tract and duodenum;
• thrombo- and leukopenia.